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IKBKG — TNFSF10
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
Complex of CASP8-FADD-IKBKG-RALBP1-TRAF2
→
TNFSF10
(increases)
Varfolomeev et al., J Biol Chem 2005*
Evidence: Here we show that Apo2L/TRAIL activates kinase pathways by promoting the association of a secondary signaling complex, subsequent to assembly of a primary, death-inducing signaling complex (DISC). The secondary complex retained the DISC components FADD and caspase-8, but recruited several factors involved in kinase activation by TNF, namely, RIP1, TRAF2, and NEMO/IKKgamma.
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NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10)
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IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
Evidence: mutant phenotype, reporter gene
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NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
Evidence: mutant phenotype, assay, reporter gene
Text-mined interactions from Literome
Siegmund et al., J Biol Chem 2001
:
As both TNF and PMA rapidly induce NF-kappaB activation this suggests that
NEMO/IKKgamma dependent activation of the NF-kappaB pathway is
necessary but not sufficient for up-regulation of
TRAIL in T cells
Tanaka et al., Mol Cancer Res 2009
(Colonic Neoplasms...) :
PRMT5 contributed to
TRAIL induced activation of
inhibitor of kappaB kinase (IKK) and nuclear factor-kappaB (NF-kappaB), leading to induction of several NF-kappaB target genes
Seo et al., Exp Mol Med 2012
:
On the other hand, kurarinone significantly inhibited
TRAIL induced
IKK activation, I?B degradation and nuclear translocation of NF-?B, as well as effectively suppressed cellular FLICE-inhibitory protein long form ( cFLIPL ) expression