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NAB2 — TNFSF10
Text-mined interactions from Literome
Wolkers et al., Blood 2012
:
Enforced expression of Nab2 prevents
TRAIL induction after restimulation of primary helpless CD8 ( + ) T cells, and expression of a dominant negative form of
Nab2 in helped CD8 ( + ) T cells
impairs their secondary proliferative response that is reversible by TRAIL blockade
Balzarolo et al., Eur J Immunol 2012
:
Furthermore, PI3K signaling is required for
NAB2 mediated
TRAIL expression
Balzarolo et al., Immunol Lett 2013
:
Provided that TRAIL plays a key role in NK cell cytotoxicity towards infected and tumor cells, we investigated whether
NAB2 also
mediates TRAIL expression in human NK cells, and if so through which mechanisms