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NFATC1 — TNF
Pathways - manually collected, often from reviews:
-
KEGG Natural killer cell mediated cytotoxicity:
NFAT5/NFATC1/NFATC2/NFATC3/NFATC4
→
TNF
(protein-protein, indirect effect)
-
NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes:
NFAT1-c-4 (dimer)/EGR4 complex (NFATC1_NFATC2_NFATC3-EGR4)
→
TNF-alpha (TNF)
(transcription, activates)
Decker et al., Nucleic Acids Res 2003, McCaffrey et al., J Biol Chem 1994, Goldfeld et al., J Exp Med 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
NFAT1-c-4 (dimer)/EGR4 complex (NFATC1_NFATC2_NFATC3-EGR4)
→
TNF-alpha (TNF)
(transcription, activates)
Decker et al., Nucleic Acids Res 2003, Barouch-Bentov et al., J Immunol 2005, McCaffrey et al., J Biol Chem 1994, Goldfeld et al., J Exp Med 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
Text-mined interactions from Literome
Kanazawa et al., J Bone Miner Res 2005
(Bone Resorption) :
Only a few TRACP ( + ) multinucleate cells were formed, and
TNF-alpha mediated
activation of JNK, NF-kappaB, and
NFATc1 was defective
Nakao et al., Biochem Biophys Res Commun 2007
:
Endogenous
TNFalpha in pOCs
induced c-Fos and
NFATc1
Yamashita et al., J Biol Chem 2007
:
We report that RANKL and
TNF can
induce osteoclast formation directly from NF-kappaB p50/p52 double knockout ( dKO ) osteoclast precursors when either c-Fos or
NFATc1 is expressed
Kaminuma et al., J Immunol 2008
:
Ectopic expression of NFATc2 but not
NFATc1 , especially its short isoform,
enhanced TNF-alpha synthesis in human T cells at the gene transcription level, whereas both NFATs augmented IL-2 expression
Yamaguchi et al., FEBS Lett 2008
(Bone Diseases...) :
Adiponectin inhibits induction of
TNF-alpha/RANKL stimulated
NFATc1 via the AMPK signaling ... Moreover, we observed that inhibition of AMP activated protein kinase abrogated gAd inhibition for
TNF-alpha/RANKL induced
NFATc1 expression
Yarilina et al., Proc Natl Acad Sci U S A 2011
:
TNF induced
NFATc1 activity primed macrophages for enhanced osteoclastogenesis in response to RANKL