◀ Back to NOTCH1
MAML1 — NOTCH1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Notch-mediated HES/HEY network:
TWIST1 (TWIST1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Kurooka et al., J Biol Chem 2000, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NCoR (NCOR1/NCOR2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
HDAC1 (HDAC1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
p300 (EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Oswald et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
p300 (EP300)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
SHARP (SPEN)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
SHARP/RBPJ complex (SPEN-RBPJ)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Notch signaling pathway:
SHARP (SPEN)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
SHARP/RBPJ complex (SPEN-RBPJ)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1)
→
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NCoR (NCOR1/NCOR2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
HDAC1 (HDAC1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
MAML1-2 (MAML1/MAML2)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
MAML1-2 (MAML1/MAML2)
→
NICD (NOTCH1)
(modification, collaborate)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
HES1 (HES1)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Castella et al., Mol Cell Biol 2000, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Fryer et al., Mol Cell 2004, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Notch-mediated HES/HEY network:
SHARP/RBPJ complex (SPEN-RBPJ)
→
RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300)
(transcription, inhibits)
Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998
Evidence: mutant phenotype, reporter gene
-
Reactome Reaction:
NOTCH1
→
MAML1
(reaction)
Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Fryer et al., Mol Cell 2004, Nam et al., Cell 2006
-
Reactome Reaction:
NOTCH1
→
MAML1
(indirect_complex)
Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Nam et al., Cell 2006
-
Reactome Reaction:
NOTCH1
→
MAML1
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Popko-Scibor et al., Biochem Biophys Res Commun 2011*
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Kim et al., Exp Cell Res 2011*
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Yatim et al., Mol Cell 2012
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Jeffries et al., Mol Cell Biol 2002*
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Kitagawa et al., Mol Cell Biol 2001*
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(direct interaction, pull down)
Wu et al., Nat Genet 2000
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(physical association, affinity chromatography technology)
Wu et al., Nat Genet 2000
-
IRef Biogrid Interaction:
MAML1
—
NOTCH1
(direct interaction, two hybrid)
Wu et al., Mol Cell Biol 2002
-
MIPS CORUM HES1 promoter-Notch enhancer complex:
HES1 promoter-Notch enhancer complex complex (CCNT1-CDK7-CDK8-CDK9-EP300-MAML1-MED1-NOTCH1-POLR2A-RBPJ-INPP5K-SUPT16H-SUPT6H)
Fryer et al., Mol Cell 2004
-
MIPS CORUM Notch1-fraction 30 complex:
Notch1-fraction 30 complex complex (MAML1-NOTCH1-RBPJ)
Jeffries et al., Mol Cell Biol 2002*
-
MIPS CORUM RBPJ-NotchIC-Mastermind complex:
RBPJ-NotchIC-Mastermind complex complex (MAML1-NOTCH1-RBPJ)
Kitagawa et al., Mol Cell Biol 2001*
-
MIPS CORUM MAML1-RBP-Jkappa-Notch1 complex:
MAML1-RBP-Jkappa-Notch1 complex complex (MAML1-NOTCH1-RBPJ)
Nam et al., Cell 2006
-
IRef Corum Interaction:
Complex of 14 proteins
(association, chromatin immunoprecipitation assay)
Fryer et al., Mol Cell 2004
-
IRef Dip Interaction:
Complex of MAML1-NOTCH1-HIF1A
(anti bait coimmunoprecipitation)
Sahlgren et al., Proc Natl Acad Sci U S A 2008*
-
IRef Dip Interaction:
MAML1
—
NOTCH1
(physical association, anti bait coimmunoprecipitation)
Moellering et al., Nature 2009*
-
IRef Dip Interaction:
MAML1
—
NOTCH1
(physical association, anti bait coimmunoprecipitation)
Sahlgren et al., Proc Natl Acad Sci U S A 2008*
-
IRef Dip Interaction:
MAML1
—
NOTCH1
(physical association, pull down)
Moellering et al., Nature 2009*
-
IRef Dip Interaction:
Complex of 31 proteins
(direct interaction, x-ray crystallography)
Arnett et al., Nature structural & molecular biology 2010*
-
Gene Ontology Complexes MAML1-RBP-Jkappa- ICN1 complex:
MAML1-RBP-Jkappa- ICN1 complex complex (NOTCH1-MAML1)
Shen et al., Genes Dev 2006*
-
IRef Hprd Interaction:
MAML1
—
NOTCH1
(in vitro)
Wu et al., Nat Genet 2000, Nam et al., J Biol Chem 2003*, Nam et al., Cell 2006
-
IRef Intact Interaction:
Complex of MAML1-RBPJ-NOTCH1-HDAC3
(association, anti tag coimmunoprecipitation)
Tong et al., EMBO Rep 2011
-
IRef Intact Interaction:
Complex of NOTCH1-RBPJ-MAML1
(physical association, x-ray crystallography)
Nam et al., Cell 2006
-
IRef Ophid Interaction:
MAML1
—
NOTCH1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Wu et al., Semin Cancer Biol 2004
(Cell Transformation, Neoplastic) :
Here, we review our current understanding of the
roles of the
MAML proteins in
Notch signaling, and their involvement in certain human cancers
Maillard et al., J Exp Med 2006
:
These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional
activation by
Notch via the
CSL/RBP-J-MAML complex
Liu et al., Cancer Biol Ther 2009
(Breast Neoplasms...) :
As expected, transformation by Notch1 was suppressed by dominant negative CSL or
MAML1 ,
inhibitors of canonical
Notch1 signaling
Köchert et al., Oncogene 2011
(Lymphoma) :
Finally, in line with the essential
role of
MAML proteins for assembly and activity of the
NOTCH transcriptional complex ( NTC ) , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
Oyama et al., Development 2011
:
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are
essential for
Notch signaling in vivo
Brimer et al., Oncogene 2012
:
Cutaneous papillomavirus E6 oncoproteins associate with
MAML1 to
repress transactivation and
NOTCH signaling
Horn et al., Proc Natl Acad Sci U S A 2012
:
Impeding
Notch mediated transcriptional
activation by conditional expression of dominant negative
Mastermind-like 1 (Maml1) resulted in a similarly distorted P-D patterning and suppressed ß-cell formation, as did conditional inactivation of the Notch target gene Hes1
Zhang et al., Development 2013
(Hyperplasia...) :
Collectively, these findings indicated that
Maml mediated
Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis and homeostasis through regulation of Klf4 and Klf5
Meyers et al., J Virol 2013
:
Cutaneous ß-human papillomavirus ( ß-HPV ) E6 proteins
inhibit NOTCH signaling by associating with the transcriptional coactivator
MAML1