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TCF15 — TNF
Text-mined interactions from Literome
Guo et al., Am J Physiol 1999
(Necrosis) :
C2 ceramide did not mimic the
effects of
TNF-alpha on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB
transcription factor
Manna et al., Biochem Pharmacol 1999
:
Suppression of
tumor necrosis factor activated nuclear
transcription factor-kappaB , activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone
Myokai et al., Proc Natl Acad Sci U S A 1999
:
A novel lipopolysaccharide induced
transcription factor regulating
tumor necrosis factor alpha gene expression : molecular cloning, sequencing, characterization, and chromosomal assignment
Otsuka et al., Cancer Res 1999
(Glioma) :
TNF-alpha activates a
transcription factor , nuclear factor-kappaB (NF-kappaB), which induces a wide variety of genes and causes pleiotrophic responses
Jaffray et al., J Surg Res 2000
(Liver Diseases...) :
Serum tumor necrosis factor (TNF) protein ( ELISA ), hepatic
TNF mRNA ( reverse transcription polymerase chain reaction ), and hepatic
activation of the
transcription factor nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined
Tolando et al., Free Radic Biol Med 2000
:
Because Se supplementation decreases cytokine induced NF-kappaB activity, whereas added H ( 2 ) O ( 2 ) is inactive and catalase does not affect the activation induced by TNF-alpha, it is concluded that only intracellularly generated H ( 2 ) O ( 2 ) has a role in
transcription factor activation by both
TNF-alpha and IL-1beta
Nagaki et al., Hepatology 2000
:
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously
activates the
transcription factor , nuclear factor-kappaB (NF-kappaB), which suppresses apoptosis by an unknown mechanism
Miyoshi et al., Am J Pathol 2001
(Cholestasis...) :
Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation, suggesting that
tumor necrosis factor-alpha was not
responsible for the activation of this
transcription factor
Frost et al., Toxicol Appl Pharmacol 2001
:
Propanil
inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the
transcription factor nuclear factor-kappab in the macrophage cell line ic-21
Haridas et al., Proc Natl Acad Sci U S A 2001
:
This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on
tumor necrosis factor (TNF) induced activation of nuclear
transcription factor-kappaB ( NF-kappaB ) in Jurkat cells ( human T cell leukemia )
You et al., Invest Ophthalmol Vis Sci 2002
:
Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB, whereas
TNF-alpha potently
induced this
transcription factor
Jeong et al., Cytokine 2002
:
Expression of
TNF-alpha and IL-6 was
regulated by a
transcription factor , nuclear factor (NF)-kappaB
Chandra et al., Chem Biol Interact 2003
:
Stimulation of the VECs with
TNF-alpha led to an increase in the DNA binding activity of the
transcription factor , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1
Zhang et al., Free Radic Biol Med 2003
:
Furthermore, treatment of HAEC with 0.5 mM DFO or NC completely inhibited
TNFalpha induced activation of the
transcription factor , specificity protein-1 (SP-1), but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression, i.e., nuclear factor kappaB (NFkappaB), activator protein-1 (AP-1), and interferon regulatory factor-1 (IRF-1)
Broussard et al., Endocrinology 2003
:
TNFalpha also
impairs the ability of IGF-I to induce expression of a key myogenic
transcription factor , myogenin
Punzón et al., Int Immunopharmacol 2003
:
At the molecular level, EXPLY-37 did not inhibit the
activation of the nuclear factor kappa B (NF-kappaB)
transcription factor by
TNF
Tomsig et al., Biochem J 2004
:
The construct was found to reduce
activation of the
transcription factor NF-kappaB ( nuclear factor-kappaB ) by
TNF-alpha
Chen et al., Arterioscler Thromb Vasc Biol 2004
:
Carvedilol inhibits
tumor necrosis factor-alpha induced endothelial
transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells
Tamaoki et al., Am J Med 2004
(Chronic Disease...) :
Macrolides
inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, and
tumor necrosis factor-alpha , perhaps by suppressing the
transcription factor nuclear factor-kappaB or activator protein-1
Zhu et al., Eur J Immunol 2005
(Inflammatory Bowel Diseases) :
In the colons, a
TNF-alpha inducing
transcription factor , LPS induced TNF-alpha factor (LITAF), was inhibited by 1,25D3, but not by calcium
Alikhani et al., J Biol Chem 2005
:
These results indicate that
TNF induces activation of the FOXO1
transcription factor , which acts as a master switch to control apoptosis
Siore et al., Am J Physiol Lung Cell Mol Physiol 2005
(Disease Models, Animal...) :
We monitored pulmonary vascular resistance, oxygenation, neutrophil count, lung edema as reflected by wet-dry weights of lung tissue, perfusate concentrations of
TNF-alpha , IL-6, and 8-isoprostane ( a marker of oxidative stress ), and
activation of the
transcription factor ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin
Ajuwon et al., J Nutr 2005
:
Palmitate activates the NF-kappaB
transcription factor and
induces IL-6 and
TNFalpha expression in 3T3-L1 adipocytes
Huber et al., Placenta 2006
:
EMSA indicated
TNFalpha induced binding of the inflammatory
transcription factor to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter
Cohen-Lahav et al., Nephrol Dial Transplant 2006
:
The aim of the present study is to examine whether this vitamin D inhibition of
TNFalpha is
mediated by its major
transcription factor , nuclear factor-kappaB (NFkappaB)
Ke et al., Am J Physiol Lung Cell Mol Physiol 2006
:
Given the fact that the
transcription factor nuclear factor of activated T cells ( NFAT )
plays an important role in the regulation of
TNF-alpha and can also be activated by ROS, in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells
Gray-Schopfer et al., Cancer Res 2007
(MAP Kinase Signaling System...) :
The survival mechanism requires nuclear factor-kappaB (NF-kappaB)
transcription factor activity, which is strongly
induced by
TNF-alpha in these cells
Ruiz et al., J Nutr 2007
(Ileitis) :
Quercetin inhibits
TNF induced NF-kappaB
transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells
Takei et al., Mol Biol Cell 2008
(Neuroblastoma...) :
We find that NGF can
induce TNF-alpha synthesis through the nuclear factor-kappaB
transcription factor
Samuel et al., Pancreatology 2008
(Disease Models, Animal...) :
In additional in vitro studies, we show that cholecystokinin- or
TNF-alpha stimulated nuclear
transcription factor kappa-B activation in AR42J cells is inhibited by dominant negative ERK2
Sheikh et al., Hepatology 2008
(Hepatitis C...) :
This
transcription factor plays a key role in the expression of cytokines,
tumor necrosis factor alpha (TNF-alpha), interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand
Huang et al., Biochem Biophys Res Commun 2008
:
Lipopolysaccharide induced TNF-alpha factor ( LITAF ), a
transcription factor , can
regulate tumor necrosis factor alpha (TNF-alpha) transcription
Di Giuseppe et al., PloS one 2009
(Silicosis) :
TNFalpha signaling is
mediated by the
transcription factor , Nuclear Factor (NF)-kappaB, which regulates genes controlling several physiological processes including the innate immune responses, cell death, and inflammation
Nikolaidis et al., Shock 2010
:
In addition, lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the
transcription factor , nuclear factor-kappaB (NF-kappaB), and significantly
increased intrapulmonary expression of
TNFalpha
Pollastri et al., Chem Biol Drug Des 2009
:
We have screened a library of natural products against an assay measuring TNF-alpha secretion in lipopolysaccharide stimulated THP-1 cells, seeking compounds capable of interfering with the
TNF-alpha inducing
transcription factor lipopolysaccharide induced TNF-alpha factor
Li et al., Cancer Lett 2010
(Colorectal Neoplasms...) :
In the search of the molecular mechanisms responsible for the sensitization effect of chrysin, we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on
TNFalpha mediated nuclear
transcription factor-kappaB ( NF-kappaB ) activation
Trinh et al., Arch Pharm Res 2009
(Pruritus) :
These curcuminoids also inhibited degranulation, protein expression of
TNF-alpha and IL-4, and
transcription factor NF-kappaB
activation in IAC induced RBL-2H3 cells
Zhang et al., Biochem Biophys Res Commun 2010
(Inflammation) :
In the present research, we showed that levels of SIRT1 mRNA and protein expression increased in TNF-alpha treated VSMCs. Overexpression of the p65/RelA subunit of NF-kappaB, a
TNF-alpha activated inflammatory
transcription factor , in A7r5 cells, upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity, while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity, but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity
Messer et al., Cytokine 1990
:
Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B
transcription factor to a high-affinity kappa B element in the TNF-beta promoter
Kim et al., Phytother Res 2011
:
Furthermore, 5-HMF significantly inhibited NF-?B
transcription factor activation in
TNF-a stimulated HUVECs
Shannon et al., Mol Cell Biol 1990
:
These results demonstrate that NF-GMa is a novel
transcription factor inducible by
TNF-alpha and binds to a common element in HGF gene promoters
Krämer et al., J Biol Chem 1995
:
Regulation of the human
TNF promoter by the
transcription factor Ets
Bergmann et al., J Immunol 1994
:
This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity, but does not modulate activation of NF-kappa B
transcription factor controlling the expression of various
TNF-alpha-inducible genes
Rhoades et al., Virus Res 1996
:
The adenoviral
transcription factor , E1A 13S,
trans-activates the human
tumor necrosis factor-alpha promoter
Manna et al., J Biol Chem 1998
:
Overexpression of manganese superoxide dismutase suppresses
tumor necrosis factor induced apoptosis and activation of nuclear
transcription factor-kappaB and activated protein-1
Manna et al., J Immunol 1998
:
TNF induced activation of another nuclear
transcription factor , AP-1, was suppressed by IL-13
Abu-Amer et al., J Biol Chem 1998
:
Tumor necrosis factor-alpha activation of nuclear
transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha
Tomita et al., J Hypertens 1998
(Inflammation) :
To determine whether the
transcription factor nuclear factor-kappaB mediated expression of these genes involved in the inflammatory
response of endothelial cells to
tumor necrosis factor-alpha , by using transcription factor decoy oligodeoxynucleotides
Handel-Fernandez et al., Int J Mol Med 1998
(Adenocarcinoma...) :
Altered binding of the NF-GMa
transcription factor is
involved in the upregulated production of
TNF-alpha by macrophages of mammary tumor bearing mice
Wang et al., Invest Ophthalmol Vis Sci 1999
:
To determine whether nuclear
transcription factor-kappaB ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in
response to interleukin-1beta (IL-1beta),
tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so, whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor, MG-132, which inhibits the degradation of I kappaB, an NF-kappaB inhibitor, thereby preventing nuclear translocation of NF-kappaB