Gene interactions and pathways from curated databases and text-mining

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IL4 — MYLIP

Text-mined interactions from Literome

Stanczyk et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid) : Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
Maurer et al., Arthritis Rheum 2010 (Scleroderma, Systemic) : TGFbeta, PDGF-B, or IL-4 reduced the levels of miR-29a in normal fibroblasts to those seen in SSc fibroblasts
Majid et al., Cancer 2010 (Neoplasm Invasiveness...) : In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin ( IL ) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters
Thapa et al., AIDS 2012 (HIV Infections...) : Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD40 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis
Rückerl et al., Blood 2012 : In vitro experiments demonstrated that miR-378-3p was specifically induced by IL-4 and revealed the IL-4-receptor/PI3K/Akt signaling pathway as a target
Kelada et al., PLoS Pathog 2013 (Inflammation...) : In contrast, IL-4 regulated miR-182 and cMaf in Th2 associed Treg cells, which mitigated IL-2 secretion, in part through repression of IL2 promoting genes
Kopriva et al., PloS one 2013 : Overexpression of miR-210 in CTBs decreased STAT6 and IL-4 while inhibition of miR-210 increased STAT6 and IL-4