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HMGCR — SERPINE1

Text-mined interactions from Literome

Haslinger et al., Kidney Int 2003 (Peritonitis) : Cultured HMC were used to examine the effect of a 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA) reductase inhibitor, simvastatin, on the expression of t-PA, PAI-1 and tissue factor after activation of the cells with tumor necrosis factor-alpha (TNF-alpha)
Dong et al., Hypertens Res 2003 (Acute-Phase Reaction...) : An HMG-CoA reductase inhibitor ( mevastatin, 10 micromol/l ) attenuated the PAI-1 production induced by IL-1beta and IL-6
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : Simvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, which is known to activate PI3K/Akt, blocks TNF-alpha- and insulin induced PAI-1 expression