◀ Back to BIRC5
BIRC5 — CASP3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CASP3
—
BIRC5
(direct interaction, pull down)
Tamm et al., Cancer Res 1998*
-
IRef Biogrid Interaction:
CASP3
—
BIRC5
(direct interaction, pull down)
Shin et al., Biochemistry 2001*
-
IRef Biogrid Interaction:
CASP3
—
BIRC5
(direct interaction, enzymatic study)
Shin et al., Biochemistry 2001*
-
IRef Hprd Interaction:
BIRC5
—
CASP3
(in vitro)
Tamm et al., Cancer Res 1998*
-
IRef Ophid Interaction:
CASP3
—
BIRC5
(aggregation, confirmational text mining)
Tamm et al., Cancer Res 1998*
-
IRef Ophid Interaction:
CASP3
—
BIRC5
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
CASP3
—
BIRC5
(aggregation, confirmational text mining)
Kasof et al., J Biol Chem 2001*
Text-mined interactions from Literome
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )