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IFNG — NOX1
Text-mined interactions from Literome
Sumi et al., Biochim Biophys Acta 2003
:
In this report, we demonstrate that
NADPH oxidase is
activated by tumor necrosis factor-alpha (TNF-alpha) plus
interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma ... Activation of
NADPH oxidase induced by TNF-alpha plus
IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression
Lopez et al., J Interferon Cytokine Res 2003
:
The effect of
IFN-gamma and TNF-alpha on the eosinophilic differentiation and
NADPH oxidase activation of human HL-60 clone 15 cells ... The aim of this study was to investigate the
effect of
interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on
NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage
Pieper et al., J Cardiovasc Pharmacol 2004
:
In splenocytes derived from treated rats but stimulated ex vivo in a mixed lymphocyte response (MLR),
interferon-gamma and cyclin D3 gene expression was
inhibited by
NOX-700 suggesting down-regulation of lymphocyte activation and proliferation by in vivo treatment
Kuwano et al., Am J Physiol Cell Physiol 2006
(Inflammation) :
Interferon-gamma activates transcription of
NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells ... A Janus protein tyrosine kinase 2 inhibitor ( AG490 ) blocked the IFN-gamma stimulated tyrosine phosphorylation of STAT1, promoter activity of the -4,831 to +195 bp region, Nox1 mRNA expression, and O ( 2 ) ( - ) production, also suggesting a crucial role of STAT1 and GAS in the
IFN-gamma stimulated transcription of the
Nox1 gene
Almeida et al., J Interferon Cytokine Res 2005
:
The aim of this work was to analyze the
effect of
Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on
NADPH oxidase activity and gp91-phox gene expression in human colostrum macrophages ( CM ), peripheral blood monocytes ( PBM ), and myelomonocytic THP-1 cells
Moriwaki et al., Kidney Int 2006
:
We determined the
effects of
IFN-gamma on O ( 2 ) ( - ) production, phosphorylation of signal transducer and activator of transcription ( STAT ) -1alpha, and the mRNA and protein expressions of p22phox and
Nox1 , components of NAD ( P ) H oxidases, in human mesangial cells ( HMCs )
Yoo et al., Neurochem Int 2008
(Encephalitis...) :
It also suppressed
LPS+IFN-gamma induced
NADPH oxidase activation and eventually, the inducible form of superoxide production
Wu et al., J Cell Physiol 2008
(Sepsis) :
LPS +
IFNgamma stimulated
NADPH oxidase activity produces ROS that activate the JNK-AP1 and Jak2-IRF1 signaling pathways required for iNOS induction
Rada et al., Contrib Microbiol 2008
:
Nox1 is highly expressed in the colon epithelium, and can be
induced by LPS or
IFN- gamma
Kuwano et al., Free Radic Biol Med 2008
:
Interleukin-1beta, flagellin,
interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly
induced Nox1 in a colon cancer cell line ( T84 ), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold
Robinson et al., Free Radic Biol Med 2010
:
Production of NO metabolites (
NOx ) and OPPC activity by RAW 264.7 cells was significantly
increased by stimulation with lipopolysaccharide (LPS) and
interferon gamma (IFNgamma) at pO ( 2 ) ranging from 0.07 to 50 %
Thelen et al., Blood 1990
:
Interferon gamma-treatment of the monocytes
had no effect on the specific activity of the cell-free
NADPH-oxidase
Obermeier et al., Biochim Biophys Acta 1995
:
Cooperative
effects of
interferon-gamma on the induction of
NADPH oxidase by retinoic acid or 1,25 ( OH ) 2-vitamin D3 in monocytic U937 cells ... The
effect of retinoic acid ( RA ), 1,25-dihydroxyvitamin D3 ( 1,25-D3 ) or human recombinant
interferon-gamma (IFN-gamma) on the induction of
NADPH oxidase was studied in premonocytic U937 cells ... In contrast, RA, 1,25-D3 or
IFN-gamma alone did not
induce NADPH oxidase activity which correlated with their failure to increase p67-phox and gp91-phox mRNA levels
Tengler et al., J Biolumin Chemilumin 1993
:
Thus, antigen induced delayed mononuclear cell chemiluminescence represents
activation of phagocyte
NADPH oxidase by
interferon-gamma generated by activated lymphocytes
Ing et al., Circ Res 1999
:
All effects of cytokines, including poly ( ADP-ribose ) polymerase cleavage, could be attributed to interleukin-1beta ;
interferon-gamma and tumor necrosis factor-alpha
had no independent effects on apoptosis or on
NOx production