◀ Back to BMP2
BMP2 — BMP3
Text-mined interactions from Literome
van der Horst et al., Bone 2002
:
BMP-3 increased gradually, particularly in the matrix formation phase
; BMP-8a was
induced from the onset of matrix maturation and mineralization, in parallel to the expression of osteocalcin ; and noggin tended to decline during the mineralization phase
Kim et al., J Biol Chem 2004
:
Its expression is stimulated by
bone morphogenetic protein (BMP)-2 treatment, the
activation of
BMP receptors and R-Smads, and the expression of Dlx5 and Runx2
Li et al., J Spinal Disord Tech 2004
:
Effect of
bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and
BMP receptors in rat intervertebral disc cells ... An in vitro experiment study using rat disc cells was carried out to determine the
effect of
bone morphogenetic protein-2 (BMP-2) on extracellular matrix production, other BMPs, and
BMP receptors ( BMPRs )
Nobta et al., J Biol Chem 2005
:
Furthermore, our data also suggest that functional Notch signaling is essential not only for
BMP2 induced osteoblast differentiation but also for
BMP signaling itself
Ryoo et al., Gene 2006
:
The establishment of an in vitro model system has enabled the investigation of intracellular events including
BMP receptor activation,
BMP-2 induced R-Smad
activation , and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2
Zachos et al., J Orthop Res 2006
:
Adenovirus ( Ad )
-BMP-2 and Ad-BMP-6 transduction
resulted in abundant
BMP-2 and BMP-6 mRNA and protein expression in monolayer culture and BMP-2 protein expression in alginate cultures
Schlueter et al., Dev Biol 2006
:
In order to assess its functional role, BMP signaling was experimentally modulated by supplying exogenous
BMP2 and by
inhibiting endogenous
BMP signaling through the addition of Noggin
Rifas et al., J Cell Biochem 2007
:
Reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis showed that T-cell cytokines
induced noggin, Runx2,
BMP-2 , and osteocalcin gene expression, while noggin alone induced
BMP-2 and osteocalcin gene expression, but not Runx2, although it increased the expression of ActRII, a receptor for BMP-2
Xia et al., J Biol Chem 2007
:
Furthermore, in BmpRII-null pulmonary artery smooth muscle cells,
BMP2 and BMP4 signaling was reduced by inhibition of endogenous RGMa expression, and RGMa mediated
BMP signaling
required ActRIIA expression
Foppiano et al., Dev Biol 2007
:
These data indicate that
BMP signaling mediates interactions between tissues in the FNP that regulate FEZ formation ; and that the correct pattern of
Bmp2 and Bmp4, but not Bmp7, expression in the FNP mesenchyme
requires signaling by the BMP pathway
Schwartz et al., J Orthop Res 2008
:
BMP-2 was stimulatory over OM, and PEMF
+ BMP-2 synergistically
increased ALP and osteocalcin
Gamer et al., Dev Dyn 2008
:
Overexpression of
BMP3 in chick wing bud at the onset of chondrogenesis, using replication competent retrovirus,
reduces BMP signaling leading to increased cell proliferation and delayed cell differentiation, resulting in expanded skeletal elements and joint fusions
Miyoshi et al., J Med Invest 2008
:
After confirming that
BMP2 could
activate the canonical
BMP-Smads signaling in HAT-7 cells, we analyzed the effects of BMP2 on 14,815 gene expressions and profiled them
Yao et al., Connect Tissue Res 2010
:
Because
BMP-2 signaling may be
augmented by
bone morphogenetic protein-3 (BMP-3) , our objective in this study was to determine if the dental follicle expresses BMP-3 and if TNF-alpha stimulates the dental follicle cells to express BMP-2 and BMP-3
Oh et al., J Bone Miner Res 2012
:
PlxnA2 was associated with both type 1 and 2
BMP receptors, and
BMP2 increased the interaction between PlxnA2 and type 1 receptors
Gerjevic et al., International journal of hepatology 2012
:
In summary, alcohol stimulates TGF-beta and
BMP2 expression, and Smad2 phosphorylation but
inhibits BMP receptor, and Smad1 and Smad5 activation
Kwon et al., Biochem Biophys Res Commun 2012
:
It was also found that TGF-ß1 but not
BMP2 induced ATP oscillations and
inhibition of TGF-ß but not
BMP signaling prevented insulin induced ATP oscillations
Chen et al., Calcif Tissue Int 1997
:
Bone morphogenetic protein 2 (BMP-2) enhances
BMP-3 , BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts ... These results suggest that
BMP-2 enhances expression of other
BMP genes during bone cell differentiation