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Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PTK2
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity)
Bao et al., Mol Cell Biol 2002* Evidence: Upon attachment to fibronectin, ECV 304 cells transfected with dn Cdc42 or dn Rac1 mutants exhibited the phosphorylated form of FAK. FAK phosphorylated at Tyr397 appeared within 60 minutes and was detected even in the presence of dn Cdc42 or dn Rac1, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.
KEGG Regulation of actin cytoskeleton:
ITGA1/ITGA10/ITGA11/ITGA2/ITGA2B/ITGA3/ITGA4/ITGA5/ITGA6/ITGA7/ITGA8/ITGA9/ITGAD/ITGAE/ITGAL/ITGAM/ITGAV/ITGAX/ITGB1/ITGB2/ITGB3/ITGB4/ITGB5/ITGB6/ITGB7/ITGB8
→
Complex of BCAR1-CRK-CRKL-PTK2
(protein-protein, activation)
KEGG Pathways in cancer:
Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1
→
PTK2
(protein-protein, activation)
KEGG Small cell lung cancer:
Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1
→
PTK2
(protein-protein, activation)