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IFNB1 — PTPN11
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., J Virol 2000
(Orthomyxoviridae Infections) :
Moreover, expression of the
NS1 protein
prevented virus- and/or double stranded RNA ( dsRNA ) -mediated activation of the NF-kappaB pathway and of
IFN-beta synthesis
Donelan et al., J Virol 2004
:
Expression of the full-length
B/NS1 protein ( 281 amino acids ), as well as either its N-terminal RNA binding domain ( amino acids 1 to 93 ) or C-terminal domain ( amino acids 94 to 281 ), in the absence of any other influenza B virus proteins
resulted in the inhibition of IRF-3 nuclear translocation and
IFN-beta promoter activation
Lo et al., J Virol 2005
(Respiratory Syncytial Virus Infections) :
Thus, RSV infection or expression of recombinant
NS1 and NS2 in epithelial host cells
causes a marked decrease in Stat2 levels and the consequent downstream
IFN-alpha/beta response
Efferson et al., J Virol 2006
:
Truncation of the NS1 protein of influenza viruses is known to result in viral attenuation due to a reduced ability of the
NS1 to
inhibit the
IFN-alpha/beta response
Mibayashi et al., J Virol 2007
:
However, the precise
effects of
NS1 on the RIG-I mediated induction of
IFN-beta have not been characterized ... We now report that the
NS1 of influenza A virus interacts with RIG-I and
inhibits the RIG-I mediated induction of
IFN-beta ... Consistent with this idea,
NS1 was also found to
inhibit IFN-beta promoter activation by IPS-1 overexpression ... Our results indicate that, in addition to sequestering dsRNA, the
NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3,
preventing the transcriptional induction of
IFN-beta
Opitz et al., Cell Microbiol 2007
:
In addition, we showed that the NS1 protein is capable to inhibit the RIG-I induced signalling, a mechanism which corresponded to the observation that only
NS1-deficient but not the wild-type virus
induced high-level production of
IFNbeta
Wilson et al., J Virol 2008
:
We report that expression of WNV
NS1 inhibits TLR3 induced transcriptional activation of the
IFN-beta promoter and of an NF-kappaB-responsive promoter
Li et al., Sheng Wu Gong Cheng Xue Bao 2012
:
Moreover, HSP27 enhanced the inhibitory
effect of
NS1 on the expression of
IFN-beta