Gene interactions and pathways from curated databases and text-mining

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HSPB3 — IL6

Text-mined interactions from Literome

De Benedetti et al., Endocrinology 2001 : Effect of IL-6 on IGF binding protein-3 : a study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritis
Chen et al., Br J Pharmacol 2006 : Signal transducer and activator of transcription protein 3 ( STAT3 ), a transcription factor involved in inflammation and the cell cycle, is activated by IL-6
Wilhelmus et al., Neurobiol Aging 2009 (Cerebral Amyloid Angiopathy, Familial) : In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions