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SLPI — SMAD3

Text-mined interactions from Literome

Sowa et al., J Bone Miner Res 2002 : A type I collagen synthesis inhibitor L-azetidine-2-carboxylic acid, as well as osteocalcin ( OCN ), significantly antagonized Smad3 stimulated ALP activity and mineralization of MC3T3-E1 cells ... In conclusion, this study showed that in mouse osteoblastic cells, Smad3 inhibited proliferation, but it also enhanced ALP activity, mineralization, and the levels of bone matrix proteins such as type I collagen ( COLI ), OPN, and MGP
Sowa et al., J Biol Chem 2002 (MAP Kinase Signaling System) : We recently demonstrated that Smad3 , a TGF-beta signaling molecule, promotes ALP activity and mineralization in MC3T3-E1 cells ... However, why the effects of TGF-beta and Smad3 on ALP activity and mineralization are different remains unknown ... The expression of dominant negative type Smad3 , Smad3DeltaC, affected neither TGF-beta activated MAPKs nor TGF-beta inhibited ALP activity ... PD98059 and curcumin enhanced Smad3 induced ALP activity and mineralization, whereas SB203580 inhibited them ... The present study indicated that TGF-beta-responsive ERK1/2 and JNK cascades negatively regulate Smad3 induced transcriptional activity as well as ALP activity and mineralization in osteoblasts
Iu et al., J Endocrinol 2005 : Dex significantly suppressed Smad3 stimulated alkaline phosphatase (ALP) activity, although it did not affect TGF-beta inhibited ALP activity in MC3T3-E1 cells ... In conclusion, the present study indicates that Dex inhibits ALP activity and type I collagen expression, presumably by suppressing Smad3 induced transcriptional activity but not by modulating Smad3 expression in osteoblastic cells
Kaji et al., Horm Metab Res 2006 : Smad3 overexpression significantly inhibited bone morphogenetic protein-2 (BMP-2) induced ALP activity in ST-2 cells, indicating that Smad3 suppresses the commitment of pluripotent mesenchymal cells into osteoblastic cells