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EPHB2 — PPARG

Text-mined interactions from Literome

Floyd et al., J Biol Chem 2002 : Taken together, these results indicate that PPARgamma is targeted to the ubiquitin-proteasome pathway for degradation under basal conditions and that IFNgamma leads to an increased targeting of PPARgamma to the ubiquitin-proteasome system in a process that is affected by ERK regulated serine phosphorylation of PPARgamma proteins
Hanlon et al., Toxicol Appl Pharmacol 2003 : This temporal separation of ERK activation from the affected PPARgamma1 expression suggests that ERK does not act directly on either PPARgamma1 transcription or receptor function
Kim et al., J Pharmacol Exp Ther 2003 (Neuroblastoma) : We also found that PPAR-gamma antagonist GW9662 ( 2-chloro-5-nitro-N-phenylbenzamide ) reversed the 15-deoxy-PGJ2 induced cell growth inhibition, PPAR-gamma expression, and activation of ERK2
Hedvat et al., Cancer Cell 2004 (MAP Kinase Signaling System...) : Inhibition of HER-kinase activation prevents ERK mediated degradation of PPARgamma
Tanabe et al., J Cell Sci 2004 : Inhibition of adipocyte differentiation by mechanical stretching through ERK mediated downregulation of PPARgamma2
Akaike et al., Mol Cell Biol 2004 : We found that activation of ERK5 induced PPARgamma1 activation in endothelial cells ( ECs )
Chen et al., J Biol Chem 2006 (MAP Kinase Signaling System) : PPARgamma also stimulates ERK1/2 phosphorylation in the intestinal epithelium in vivo ... PPARgamma induces the p110alpha subunit of phosphoinositide 3-kinase (PI3K), and inhibition of PI3K blocks PPARgamma dependent phosphorylation of MEK1 Ser ( 298 ), activation of ERK1/2 , and EMT
Winn et al., J Biol Chem 2006 (Carcinoma, Non-Small-Cell Lung...) : These data suggest that ERK5 dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in NSCLC
Li et al., J Cell Physiol 2006 (Carcinoma, Non-Small-Cell Lung) : Inhibition of ERK1/2 by U0126 also led to a significant decrease in the level of PPARgamma , indicating a positive cross-talk between PPARgamma and ERK1/2 or an auto-regulatory feedback mechanism to amplify the effect of ERK1/2 on cell growth arrest and apoptosis
Kim et al., Biochem Biophys Res Commun 2006 : Pretreatment with bisindolylmaleimide I or NAC blocked TPA induced phosphorylation of extracellular signal regulated kinase ( ERK ), suggesting that ERK mediated signaling is also involved in the induction of PPARgamma
Turturro et al., Am J Physiol Cell Physiol 2007 : These results are consistent with three pathways through which glitazones may act in effecting metabolic processes ( ammoniagenesis and gluconeogenesis ) as well as cellular growth : 1 ) PPAR-gamma dependent and PPAR-gamma independent pathways, 2 ) P-ERK activation, and 3 ) mitochondrial AMPK activation
Kim et al., FEBS Lett 2007 (Fibrosarcoma...) : Pro-MMP-2 activation by the PPARgamma agonist, ciglitazone, induces cell invasion through the generation of ROS and the activation of ERK
Miksa et al., J Immunol 2007 (Endotoxemia...) : We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP dependent pathway and Pyk-2-ERK1/2 dependent induction of PPAR-gamma
Hosooka et al., Nat Med 2008 (Hypertrophy...) : These results indicate that Dok1 promotes adipocyte hypertrophy by counteracting the inhibitory effect of ERK on PPAR-gamma and may thus confer predisposition to diet induced obesity
Wu et al., J Cell Mol Med 2010 (MAP Kinase Signaling System) : Serum regulates adipogenesis of mesenchymal stem cells via MEK/ERK dependent PPARgamma expression and phosphorylation
Kim et al., Cell Mol Life Sci 2009 : Phosphorylated ERK1/2 , activated by indenone, affects the localization of PPAR gamma , suggesting a mechanism for indenone-inhibition of adipogenesis in 3T3-L1 preadipocyte cells
Luconi et al., Steroids 2010 : Among them, ERK can be positively/negatively regulated by PPARgamma ligands, as in endothelial cells, where TZDs exert anti-inflammatory effects through a novel mechanism involving a rapid inhibition of ERK1/2 phosphorylation/activation
Biyashev et al., J Biol Chem 2010 (MAP Kinase Signaling System) : We demonstrate that Erk5 phosphorylation allows activation of PPARgamma transcription factor by displacement of SMRT co-repressor
Yang et al., Life Sci 2010 : These results showed that PEDF promotes IL-10 expression at transcriptional level, and that this is achieved through the ERK2/p38MAPK dependent PPARgamma expression
Mahali et al., Biochem Pharmacol 2012 (Diabetes Complications) : Beta-D-glucoside protects against advanced glycation end products ( AGEs ) -mediated diabetic responses by suppressing ERK and inducing PPAR gamma DNA binding