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CTNNB1 — PTGS2

Text-mined interactions from Literome

Howe et al., Cancer Res 1999 (Breast Neoplasms...) : Expression of the inducible prostaglandin synthase cyclooxygenase-2 appears critical for intestinal tumorigenesis resulting from APC mutation, suggesting that cyclooxygenase-2 might be a transcriptional target for beta-catenin/Tcf complexes
Kim et al., Biochem Biophys Res Commun 2002 (Arthritis) : Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes ... We investigated in this study the role of beta-catenin in the IL-1beta regulation of COX-2 expression in articular chondrocytes ... Inhibition of beta-catenin degradation by the treatment of cells with LiCl or proteasome inhibitor stimulated expression of COX-2 , indicating that transcriptionally active beta-catenin is sufficient to induce COX-2 expression ... This was demonstrated further by the observation that ectopic expression of transcriptionally competent beta-catenin stimulated expression of COX-2
Araki et al., Cancer Res 2003 : Mutant beta-catenin expression up-regulated the COX-2 promoter activity and the endogenous COX-2 mRNA expression in HuH7, hepatocellular carcinoma cell line, which is partially abrogated by cotransfection with a dominant negative Tcf-4 expression vector ... Although beta-catenin alone did not increase COX-2 protein to detectable levels in HuH7 cells, coexpression of both mutant beta-catenin and mutant K-ras increased COX-2 protein expression, which is consistent with the previous reports that K-ras can stabilize COX-2 mRNA
Mori et al., Eur J Cancer Prev 2002 (Cell Transformation, Neoplastic...) : Expression of these beta-catenin accumulated crypts (BCAC) is markedly suppressed by a chemopreventive cyclooxygenase-2 inhibitor, celecoxib
Liu et al., J Biol Chem 2004 (Colorectal Neoplasms) : To establish a role for PEA3 to beta-catenin induced COX-2 , we transfected RKO cells with beta-catenin and found that beta-catenin increased PEA3 expression
Lee et al., Nucleic Acids Res 2006 : beta-Catenin , a key transcription factor in the Wnt signal pathway, activates transcription of COX-2
Lee et al., Cancer Res 2007 (Adenocarcinoma...) : Significantly, the cytoplasm expressed RNA intramer reverted the beta-catenin induced COX-2 and cyclin D1 mRNA stabilization
Wang et al., Mol Biol Cell 2009 (Carcinoma, Non-Small-Cell Lung) : These affects were mediated through COX-2 dependent activation of beta-catenin signaling and inhibition of apoptosis