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IL8 — PAH

Text-mined interactions from Literome

Pei et al., Cytokine 2002 : However, it is unknown whether polycyclic aromatic hydrocarbons (PAH) , mainly existed in most airborne particulates, can separately induce IL-8 expression ... We have assessed the effect of adenovirus mediated overexpression of the NF-kappaB inhibitor, IkappaBalpha on PAH induced IL-8 expression in A549 cell line ... This suggests that PAH induced IL-8 gene regulation may be mediated by NF-kappaB ... These data indicate that PAH alone, either B [ a ] P or 1-NP, is sufficient to stimulate NF-kappaB activation and IL-8 transcription
Goulaouic et al., J Immunotoxicol 2008 (Inflammation) : PAH induced significant secretion of IL-1beta, IL-8 , and IL-12 after 24 or 48 hr of treatment, an effect reinforced by LPS stimulation ; no effect on IL-10 secretion was noted