Gene interactions and pathways from curated databases and text-mining

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LCN2 — RELA

Text-mined interactions from Literome

Cowland et al., J Immunol 2003 : TNF-alpha activation of NF-kappaB , in contrast, did not increase NGAL synthesis, even though induced binding of NF-kappaB to the NGAL promoter was observed in vitro
Sousa et al., FASEB J 2005 (Amyloid Neuropathies, Familial) : Biglycan, NGAL , and MMP-9 are transcriptionally up-regulated by NF-kappaB , a transcription factor that is activated in FAP nerves and SG
Bu et al., Am J Pathol 2006 (Carotid Artery Injuries) : The present study reveals a previously unrecognized vascular response to an-gioplastic injury, characterized by NF-kappaB dependent expression of NGAL in vascular SMCs. Further-more, SMC produced NGAL interacts with MMP-9, a mechanism by which NGAL may modulate MMP-9 proteolytic activity in the vascular repair process
Matsuo et al., Biochem J 2007 : The activation of the NGAL promoter by transfection of IkappaB-zeta and NF-kappaB was suppressed in C/EBPbeta depleted cells
Bolignano et al., Cancer Lett 2010 (Neoplasm Invasiveness...) : Moreover, in thyroid carcinomas, NGAL is strongly induced by NF-kB , an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development