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APCS — RELA
Text-mined interactions from Literome
Cannons et al., Immunity 2004
:
SAP regulates T ( H ) 2 differentiation and PKC-theta mediated activation of
NF-kappaB1
Thomas et al., J Immunol 2005
:
Activation of
APCs via TLRs
leads to activation of
NF-kappaB , a key transcription factor in cells of the immune system most often associated with induction of Th1-type and proinflammatory responses ... This observation led us to ask whether LNFPIII activated
APCs were differentially
activating NF-kappaB , and if so, could this partly account for how DCs mature in response to these two different pathogen associated molecular patterns ( PAMPs ) ... In this study, we show that LNFPIII-Dex stimulation of
APCs induces rapid, but transient
NF-kappaB translocation and activity in the nucleus, in comparison with the persistent activation induced by LPS
Kammanadiminti et al., Infect Immun 2007
:
SAP induced phosphorylation of p65 and
enhanced NF-kappaB transcriptional activity, which are phosphatidylinositol 3-kinase ( PI3 kinase ) dependent
Cen et al., J Immunol 2009
:
Prior studies demonstrate that
SAP enhances TCR induced activation of
NF-kappaB in CD4 ( + ) T cells