◀ Back to TNF

CD44 — TNF

Text-mined interactions from Literome

Grünberg et al., Tumour Biol 2000 (Breast Neoplasms) : Furthermore, CEA, ICAM-1 and CD44v6 were increased by TNF-alpha plus calcitriol
Reid et al., Immunol Invest 2000 : This study used flow cytometry to assess the effects of recombinant IFN-gamma and TNF-alpha on CD44 expression and hyaluronan binding by the rat small intestinal epithelial cell lines, RIE and IEC 6
Barshishat et al., Clin Exp Metastasis 2002 (Adenocarcinoma...) : TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells
Gee et al., J Immunol 2002 : Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells : distinct involvement of c-Jun N-terminal kinase in LPS induced CD44 expression ... We demonstrate the involvement, at least in part, of p38 MAPK in TNF-alpha induced CD44 expression in both monocytes and promonocytic THP-1 cells
Speciale et al., J Cell Physiol 2003 (Astrocytoma) : 1-40 Beta-amyloid protein fragment modulates the expression of CD44 and CD71 on the astrocytoma cell line in the presence of IL1beta and TNFalpha
Gee et al., J Biol Chem 2003 : Tumor necrosis factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen activated protein kinase in lipopolysaccharide stimulated human monocytic cells ... In this study, we show that LPS induced CD44 mediated HA (CD44-HA) binding in monocytes is regulated by endogenously produced tumor necrosis factor (TNF)-alpha and IL-10 ... LPS induced CD44-HA binding in THP-1 cells was regulated by endogenously produced TNF-alpha ... Blocking TNF-alpha production by PD98059, a p42/44 inhibitor, significantly reduced the LPS induced sialidase activity and CD44-HA binding ... Subsequently, TNF-alpha mediated p38 MAPK activation induced sialidase activity and CD44-HA binding ... Taken together, our results suggest that TNF-alpha induced p38 MAPK activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells
De Saint Jean et al., Exp Eye Res 2004 : In the primary cultured cells, TNFalpha induced an important upregulation of ICAM-1, Fas and CD40 whereas CD44 and CD63 were significantly decreased
Mishra et al., J Biol Chem 2005 (Calcium Signaling) : We previously demonstrated that the c-Jun N-terminal kinase (JNK), a mitogen activated protein kinase ( MAPK ), differentially regulated LPS- but not TNF-alpha induced CD44 expression in monocytic cells ... Furthermore, TNF-alpha induced CD44 expression was regulated by AP-1 through the activation of the CaMK-II pathway, whereas LPS induced CD44 transcription was regulated specifically by Egr-1 through JNK activation
Bussini et al., Immunity & ageing : I & A 2005 : Heparan sulfate proteoglycan induces the production of NO and TNF-alpha by murine microglia
Li et al., Cancer Immunol Immunother 2006 (Neoplasms) : The TM-TNFalpha expressing tumors up-regulated Fas ( CD95 ) expression and inhibited the expression of tumor metastasis associated molecule CD44v3
Muthukumaran et al., Mol Cancer Res 2006 (Neoplasm Invasiveness...) : However, little is known about the role of TNF-alpha in CD44 expression of cancer cells ... We studied the effect of TNF-alpha on ovarian cancer cells viability, CD44 expression, and in vitro migration/invasion
Campanero et al., Eur J Immunol 1991 : Protease inhibitors virtually abrogated the TNF-alpha induced down-regulation of CD43 and CD44 expression, but not that of LAM-1, suggesting the involvement of a protease activity in this process
Baj-Krzyworzeka et al., Immunol Lett 2007 (Neoplasms) : Induction of TNF synthesis was CD44 dependent as blocking of CD44 on monocytes abolished its secretion
Swerlick et al., J Invest Dermatol 1991 : ICAM-1, but not LFA-3 or CD44 , was increased in expression in a dose- and time dependent manner by interleukin 1 (IL-1) alpha, tumor necrosis factor (TNF) alpha, lipopolysaccharide (LPS), or interferon (IFN) gamma
Campo et al., Biochim Biophys Acta 2009 : HA treatment produced different effects : low MW HA up-regulated CD44 expression, increased PKCdelta and PKCepsilon levels, and enhanced inflammation in untreated chondrocytes ; while in PMA treated cells it increased CD44, PKCdelta, PKCepsilon, NF-kB, TNF-alpha , IL-1beta, MMP-13, and iNOS expression and enhanced the effects of PMA ; medium MW HA did not exert action ; high MW HA had no effect on untreated chondrocytes ; however, it reduced PKCdelta, PKCepsilon, NF-kB activation and inflammation in PMA stimulated cells
Takahashi et al., J Biol Chem 2010 (Fibrosis) : Tumor necrosis factor-alpha regulates transforming growth factor-beta dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction ... TNF-alpha promoted CD44 expression and moesin phosphorylation by protein kinase C, leading to the pericellular interaction of hyaluronan and CD44
Li et al., Biomed Pharmacother 2012 (Breast Neoplasms...) : Regulation of CD44 expression by tumor necrosis factor-a and its potential role in breast cancer cell migration ... In the current investigation, we investigated the effect of TNF-a on BC cells ( MCF-7 and MDA-MB-231 ) viability, CD44 expression, and in vitro migration ... We found that TNF-a down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells ... In MDA-MB-231 cells, TNF-a up-regulated CD44s , CD44v3 and CD44v6 expression via p38 pathway
Zembala et al., Int J Cancer 1994 (Colorectal Neoplasms...) : However, anti-CD44 and anti-HLA-DR MAbs effectively blocked TNF release and TNF-mRNA induction in monocytes
Osada et al., J Invest Dermatol 1995 : Up-regulation of CD44 expression by tumor necrosis factor-alpha is neutralized by interleukin-10 in Langerhans cells ... We examined the modulatory effects of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 on the CD44 expression in LC ... We found 1 ) that TNF-alpha significantly up-regulated the expression of CD44 in a concentration dependent manner, 2 ) that IL-10 down-regulated the expression of CD44 in a concentration dependent manner, 3 ) that the effect of TNF-alpha or IL-10 was readily detectable as early as 24 h after the initiation of culture, and 4 ) that the simultaneous addition of TNF-alpha and IL-10 mutually neutralized the effect of each other ... These data suggest that in the epidermal microenvironment the expression of CD44 in LC may be reciprocally regulated by TNF-alpha and IL-10, both of which are known to be produced by surrounding keratinocytes
Uhl-Steidl et al., Oncology 1995 (Carcinoma...) : Interferon-alpha, interferon-gamma, tumor necrosis factor , transforming growth factor-beta, all-trans retinoic acid and cisplatin did not affect CD44v expression
Noble et al., J Clin Invest 1993 (Fibrosis...) : These results indicate that hyaluronate activation of CD44 induces cytokine expression and macrophage derived IGF-1 production is dependent on TNF alpha expression
Schwarting et al., Scand J Rheumatol 1996 : IL-1 beta showed the strongest stimulatory effect on the expression of ICAM-1, TNF-alpha preferentially induced the expression of VCAM-1 and CD-44 , and Et-1 strongly stimulated the upregulation of CD-44 expression
Galandrini et al., Eur J Immunol 1996 : Furthermore, the drug also prevents CD44 mediated TNF-alpha production and CD69 expression
Le Naour et al., AIDS Res Hum Retroviruses 1997 (HIV Infections) : In addition, pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor, RP 55778, or with MAbs directed against IL-1beta, confirmed the role of TNF-alpha and IL-1beta in the regulation of CD18, CD44 , and CD54 expression
Maki et al., Leukemia 1998 (Burkitt Lymphoma...) : TNF-alpha , but not IFN-gamma also induced the activation of LFA-1, CD44 and beta1 integrins on SR-91 cells