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NOX4 — TNF

Text-mined interactions from Literome

Katsuyama et al., Endocrinology 1999 : Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate ( NOx ) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively
Li et al., Circ Res 2002 : These data show that endothelial cell p47(phox) is critical in the upregulation of NADPH oxidase activity by PMA and TNFalpha
Thabut et al., J Biol Chem 2002 : Tumor necrosis factor-alpha increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility
Frey et al., Circ Res 2002 : PKCzeta regulates TNF-alpha induced activation of NADPH oxidase in endothelial cells
Sumi et al., Biochim Biophys Acta 2003 : In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma ... Activation of NADPH oxidase induced by TNF-alpha plus IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression
Chen et al., Am J Physiol Heart Circ Physiol 2004 : These data suggest that ROS such as superoxide and H ( 2 ) O ( 2 ) derived from Rac1 activated NADPH oxidase mediate TNF-alpha induced MCP-1 expression in endothelial cells
Lopez et al., J Interferon Cytokine Res 2003 : The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells ... The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage
Shin et al., Circulation 2004 (Arteriosclerosis) : Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only NAD ( P ) H oxidase dependent superoxide production but also TNF-alpha and interleukin-1beta release and restored viability
Yamagishi et al., Drugs Exp Clin Res 2003 : Nifedipine completely inhibited TNF-alpha induced nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase activity in HUVEC
Yamagishi et al., J Cardiovasc Pharmacol 2004 : Azelnidipine also completely prevented TNF-alpha induced increase in NADPH oxidase activity in HUVEC
Yamagishi et al., J Mol Cell Cardiol 2004 : Further, PEDF completely prevented the TNF-alpha induced increase in NADPH oxidase activity
Min et al., Glia 2004 (Encephalitis) : Expression of IL-1beta, TNF-alpha , and iNOS in ganglioside treated cells was significantly reduced in the presence of inhibitors of PKC ( GF109203X, Go6976, Ro31-8220, and rottlerin ) and NADPH oxidase ( diphenyleneiodonium chloride [ DPI ] )
Tojo et al., J Hypertens 2005 (Hypertension, Renal) : Nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase is regulated by angiotensin II, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Li et al., Mol Cell Biol 2005 : In coronary microvascular EC from p47phox-/- mice, TNF-alpha induced NADPH oxidase activation, ERK1/2 activation, and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited
Zhang et al., Di Yi Jun Yi Da Xue Xue Bao 2005 : Inhibition of NADPH oxidase by apocynin and p38 phosphorylation by SB203580 could both effectively block AOPP-BSA induced TNF-alpha secretion
Almeida et al., J Interferon Cytokine Res 2005 : The aim of this work was to analyze the effect of Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in human colostrum macrophages ( CM ), peripheral blood monocytes ( PBM ), and myelomonocytic THP-1 cells
Liang et al., J Cell Physiol 1992 : Activation of the NADPH oxidase by phorbol myristate acetate, F-, N-formyl-methionyl-leucyl-phenylalanine ( FMLP ), or tumor necrosis factor (TNF) dramatically reduced autofluorescence levels
Cheranov et al., Am J Physiol Cell Physiol 2006 (Calcium Signaling) : In summary, our data indicate that TNF-alpha activates NAD ( P ) H oxidase , resulting in an increase in intracellular H ( 2 ) O ( 2 ) that stimulates Ca ( 2+ ) sparks and transient K ( Ca ) currents, leading to a reduction in global [ Ca ( 2+ ) ] ( i ), and vasodilation
Jiang et al., Hypertension 2006 : Activation of NADPH oxidase by tumor necrosis factor (TNF) alpha increased generation of reactive oxygen species
Gao et al., Circulation 2007 (Vascular Diseases) : Increases in TNF expression induce activation of NAD ( P ) H oxidase and production of reactive oxidative species, leading to endothelial dysfunction in type 2 diabetes
Gauss et al., J Leukoc Biol 2007 : Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha ... To gain a better understanding of the mechanisms involved in NADPH oxidase regulation by TNF-alpha , we evaluated transcriptional regulation of oxidase genes in MonoMac1 cells and human monocytes
Kim et al., Mol Cell 2007 (Necrosis) : TNF induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death ... Here we show that TNF also activates the Nox1 NADPH oxidase in mouse fibroblasts when cells undergo necrosis
Vanden Berghe et al., Mol Cell 2007 (Necrosis) : In a recent issue of Molecular Cell, Kim et al. ( 2007 ) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex
Yoshida et al., Int Immunopharmacol 2008 : Together, these results suggest that Nox2 and Nox4A enzymes are induced by TNF-alpha endowing HCAEC with enhanced ROS generating activity, which may play a role in the initial endothelial dysfunction through oxidative stress
Turchan-Cholewo et al., Antioxid Redox Signal 2009 : Furthermore, inhibition of NADPH oxidase attenuated Tat induced release of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF) , and monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
Basuroy et al., Am J Physiol Cell Physiol 2009 (Inflammation) : TNF-alpha rapidly increased NADPH oxidase activity in CMVEC
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : gp91(phox)-NADPH oxidase mediated calpain-1 activation induces caspase-3 activation and TNF-alpha expression in cardiomyocytes during LPS stimulation
Yin et al., J Pharmacol Sci 2009 (Fatty Liver, Alcoholic) : In vitro studies showed that MO was able to protect RAW 264.7 cells from ethanol induced production of tumor necrosis factor-alpha , reactive oxygen species, and superoxide anion radicals ; the activation of NADPH oxidase ; and subsequent cell death
Wing et al., Experimental biology and medicine (Maywood, N.J.) 2009 (Atherosclerosis) : Estrogen at physiological concentration inhibited tumor necrosis factor-alpha stimulated NAD ( P ) H oxidase activity in both cultured smooth muscle cells and peritoneal macrophages
Mazor et al., Hypertension 2010 (Disease Models, Animal...) : Tumor necrosis factor-alpha plays a role in activation of the polymorphonuclear leukocyte NADPH oxidase , thereby contributing to systemic OS, inflammation, and the development of hypertension in this model
Zhang et al., Am J Physiol Heart Circ Physiol 2010 (Diabetes Mellitus, Type 2...) : This improvement is due to the role of resveratrol in inhibiting TNF-a induced NF-?B activation, therefore subsequently inhibiting the expression and activation of NAD ( P ) H oxidase and iNOS as well as increasing eNOS expression in type 2 diabetes
Boussetta et al., Blood 2010 : Tumor necrosis factor-a (TNF-a) , a major mediator of inflammation, does not activate NADPH oxidase but induces a state of hyperresponsiveness to subsequent stimuli, an action known as priming
Volk et al., J Innate Immun 2011 (MAP Kinase Signaling System...) : PMN generated reactive oxygen species ( ROS ) in response to TNF-a alone, and NADPH oxidase activity increased in response to stimulation with formyl-Met-Leu-Phe after priming
Katsume et al., Arterioscler Thromb Vasc Biol 2011 (Aortic Diseases...) : Lysophosphatidylcholine activated PYK2 induced NADPH oxidase mediated ROS generation and ROS mediated synthesis of tumor necrosis factor-a (TNFa) , vascular cell adhesion molecule-1 ( VCAM-1 ), monocyte chemotactic protein-1 (MCP-1), and p21Cip1/Ets-1
Lee et al., J Cell Physiol 2011 : Here, we report that TNF-a induced cPLA(2) protein and mRNA expression, PGE ( 2 ) production, and phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK1/2, which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine, ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ], MEK1/2 ( U0126 ), p38 MAPK ( SB202190 ), and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2, p47(phox), MEK1, p42, p38, or JNK2
Hopps et al., J Sports Med Phys Fitness 2011 (Obesity) : TNF-a and IL-6, produced by adipose tissue, increase NADPH oxidase activity activating protein kinase C and NF?B leading to an higher oxidative stress
Donini et al., Prostate 2012 (Prostatic Neoplasms) : LNCaP enhance IL-1ß, IL-23, IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase unrelated mechanisms
Tarr et al., Cell Signal 2012 : The deficiency in p47phox prevented TNF-a induced NADPH oxidase and C2GNT activity and adherence to endothelial cells
Lai et al., Endocrinology 2012 : Consistent with this, rotenone, an antagonist of mitochondrial complex I, inhibited TNF induction of Msx2 and Nox2 , whereas pyruvate, an anapleurotic mitochondrial metabolic substrate, enhanced induction
Mangner et al., PloS one 2013 : Furthermore, TNF-a led to an increased NAD ( P ) H oxidase activity in both sedentary and exercised mice whereas xanthine oxidase activity and intramitochondrial ROS production was only enhanced in sedentary animals by TNF-a
Spencer et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : Cumulatively, these results demonstrate that NOX2 and its activator subunits ( p47(phox) and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly, in the absence of Kupffer cells and NOX2, NOX1 played a dominant role in TNF-a production following hepatic I/R
Sriramula et al., PloS one 2013 : Moreover, brain targeted TNF blockade significantly reduced Ang II-induced NOX-2 and NOX-4 mRNA and protein expression in the PVN
Dusi et al., J Immunol 1996 : Taken together, these findings demonstrate that TNF activates the NADPH oxidase through stimulation of tyrosine kinases, whose function is cytoskeleton dependent, and raise the problem of whether the activation of this respiratory burst involves signals arising from TNF activated beta2 integrins
Ing et al., Circ Res 1999 : All effects of cytokines, including poly ( ADP-ribose ) polymerase cleavage, could be attributed to interleukin-1beta ; interferon-gamma and tumor necrosis factor-alpha had no independent effects on apoptosis or on NOx production