UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

GLI3 — WNT16

Pathways - manually collected, often from reviews:

KEGG Hedgehog signaling pathway: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
KEGG Pathways in cancer: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
KEGG Basal cell carcinoma: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)

Text-mined interactions from Literome

Ulloa et al., Curr Biol 2007 : Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling
Alvarez-Medina et al., Development 2008 : Additionally, we show that Gli3 expression is controlled by Wnt activity ... These indicated that dorsal Gli3 expression might be directly regulated by canonical Wnt activity
Martinez-Ferre et al., J Neurosci 2013 : Early Wnt expression in the ZLI regulates Gli3 and L-fng to generate a permissive territory in which Shh is progressively induced by planar signals of the basal plate