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E2F1 — HDAC3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RBBP4 (RBBP4) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC3 (HDAC3) → RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC3 (HDAC3) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 11 proteins (in vivo) Nagl et al., EMBO J 2007
• IRef Hprd Interaction: Complex of 100 proteins (in vivo) Nagl et al., EMBO J 2007

Text-mined interactions from Literome

Boutillier et al., J Neurochem 2003 : Taken together, our results suggest that, in neuroprotective conditions, histone deacetylase activity allows a constitutive repression of the e2f-1 gene in mature neurones in order to ensure survival
Park et al., Biochem Biophys Res Commun 2012 : Here, we identified and characterized a regulatory region of Lhx2 gene which mediates responses to two different signals such as inhibition of HDAC3 and stimulation by E2F1