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MAP3K11 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP complex (RAC1)
→
MAP3K11 (MAP3K11)
(translocation, activates)
Teramoto et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
WikiPathways Insulin Signaling:
RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10
→
MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lambert et al., J Biol Chem 2002
:
We found that the MLK3 serine/threonine kinase activated JNK and p70 ( S6K ), whereas activation of p70 ( S6K ) by
Rac ( 61L ) was significantly
inhibited by dominant negative
MLK3
Zhang et al., J Neurochem 2006
(Brain Ischemia...) :
Akt
inhibits MLK3/JNK3 signaling by inactivating
Rac1 : a protective mechanism against ischemic brain injury