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FOXO3 — FOXO4
Pathways - manually collected, often from reviews:
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(transcription, inhibits)
Seoane et al., Cell 2004
Evidence: mutant phenotype, reporter gene, physical interaction
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NCI Pathway Database Class I PI3K signaling events mediated by Akt:
FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999, Kops et al., Nature 1999, Rena et al., J Biol Chem 1999, Brunet et al., J Cell Biol 2002
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO1-3a-4/beta catenin complex (FOXO3_FOXO4_FOXO1-CTNNB1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Essers et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
→
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(modification, collaborate)
Gomis et al., Cancer Cell 2006
Evidence: physical interaction
-
NCI Pathway Database Class I PI3K signaling events mediated by Akt:
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Kino et al., Diabetes 2005
(Acquired Immunodeficiency Syndrome...) :
This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative effect of insulin on
Foxo3a induced transactivation of a
FOXO-responsive promoter
Lynch et al., Mol Cancer Res 2005
(Disease Progression...) :
Together, reduced
FOXO3a expression coupled to FOXO3a hyperphosphorylation would
suppress FOXO transcriptional activity
Essaghir et al., J Biol Chem 2009
:
The transcription of
FOXO genes is
stimulated by
FOXO3 and repressed by growth factors ... Conversely, ectopic
FOXO3 activation blocked the proliferation of fibroblasts and
induced the expression of FOXO1,
FOXO4 , and p27-KIP1 ... Altogether, our results suggest that the expression of FOXO1 and
FOXO4 genes is
stimulated by
FOXO3 and possibly by other FOXO factors in a positive feedback loop, which is disrupted by growth factors