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LMO4 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer ) complex (STAT3) (modification, activates)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, activates)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer ) complex (STAT3) (modification, activates)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) (modification, activates)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (STAT3) (modification, activates) Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Novotny-Diermayr et al., J Biol Chem 2005 : Overexpression of LMO4 enhanced the transcriptional activity and target gene expression of Stat 3 ( signal transducers and activators of transcription 3 )
Gomez-Smith et al., Cell Mol Life Sci 2010 : Thus, our results indicate that LMO4 enhances GCSF induced Stat3 signaling in neurons, in part by sequestering HDAC