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HLA-DRB1 — NFKB1
Text-mined interactions from Literome
Gibson et al., Mol Cell Biol 2000
:
Inhibition of
NF-kappaB activation by expression of kinase-inactive MEK kinase 1 ( MEKK1 ) or dominant negative IkappaB ( DeltaIkappaB )
blocked the increase in
DR4 and DR5 expression following etoposide treatment
Kim et al., Biochem Biophys Res Commun 2002
:
In addition, we previously found that cross linking of
MHC class II molecules using anti-MHC class II antibodies
inhibited NF-kappaB activation in resting B cells isolated from mouse spleen
Shetty et al., Apoptosis 2002
:
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) up-regulates
death receptor 5 (DR5) mediated by
NFkappaB activation in epithelial derived cell lines
Chen et al., Cancer Res 2003
(Breast Neoplasms) :
Overexpression of a transdominant negative mutant of the inhibitory protein I kappa B alpha results in down-regulation of constitutively active
NF-kappa B ,
induction of
DR5 , and tumor necrosis factor receptor (TNFR) 1-associated death domain expression and enhancement of TRAIL sensitivity
Singh et al., Oncogene 2005
(Breast Neoplasms) :
HDAC inhibitors synergized with TRAIL by
inducing DRs
DR4/TRAIL-R1 and DR5/TRAIL-R2 through
NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Shetty et al., Mol Cell Biol 2005
(Breast Neoplasms) :
The mechanism of
NF-kappaB induced
DR5 expression is, however, unknown ... This provides a mechanism for regulating
NF-kappaB mediated
DR5 expression and could explain the differential roles NF-kappaB plays in regulating apoptosis
Graham et al., Cell cycle (Georgetown, Tex.) 2005
:
NFkappaB activation
induces death receptor 5 (DR5) expression following DNA damaging agent etoposide treatment but not following growth factor EGF treatment
Kumari et al., Biochem Biophys Res Commun 2005
(Neoplasms, Experimental) :
The enhanced
NFkappaB activity
resulted in the elevation of TRAIL and its receptor
DR4 , both known to induce apoptosis
Wosik et al., J Neurol Sci 2007
:
TNFR1 ligation
induces NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8, as well as adhesion molecules ICAM-1 and VCAM-1, while Fas and
DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2, p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs
Shankar et al., Molecular cancer 2008
(Neoplasm Metastasis...) :
In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4,
TRAIL-R2/DR5 , Bax, Bak, p21/WAF1, and p27/KIP1, and
inhibited the activation of
NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL
Mendoza et al., Apoptosis 2008
:
Death receptor-4 (DR4) expression is
regulated by transcription factor
NF-kappaB in response to etoposide treatment ... Herein, we determined that transcription factor
NF-kappaB plays a role in genotoxin induced
DR4 expression ... Moreover, expression of the p65 subunit of
NF-kappaB is
sufficient to increase
DR4 protein levels ... Taken together,
NF-kappaB plays a role in up-regulation of
DR4 following etoposide treatment
Chen et al., J Immunol 2008
:
Both p53 small interfering RNA and
NF-kappaB inhibitor
suppressed DR5 expression, strengthening the significance of p53 and NF-kappaB in DR5 transcription
Trede et al., J Immunol 1993
(Leukemia, Monocytic, Acute) :
Induction of both NF-kappa B DNA binding proteins and NF-kappa B enhancer function was down-regulated by inhibitors of protein kinase C and protein tyrosine kinase, indicating a role for these protein kinases in the
induction of
NF-kappa B by
MHC class II ligands
Grammer et al., J Immunol 1998
(Burkitt Lymphoma) :
By contrast, induction of apoptosis,
activation of
NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54,
MHC class II , and CD95 were unaffected by the TRAF3 dominant negative