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PRKAR2B — PTHLH
Text-mined interactions from Literome
Jemtland et al., J Bone Miner Res 1999
(Osteosarcoma) :
Here we have characterized alternative PTHrP mRNA 3 ' splicing variants, encoding PTHrP isoforms of 139, 141, and 173 amino acids, and studied the
regulation of
PTHrP and its mRNAs by activated
PKA and PKC in two human osteoblast-like cell lines ( KPDXM and TPXM ) ... Activation of
PKA or PKC
resulted in different effects on
PTHrP and its mRNAs in the two cell lines
Deckelbaum et al., J Cell Sci 2002
:
Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes
PTHrP mediated activation of
PKA ... Conversely, overexpression of Ihh/N-Ihh or exogenous treatment with N-Shh led to dampening of
PTHrP mediated activation of
PKA
Yao et al., Med Sci Monit 2003
:
The specific
PKA inhibitor
reduces MCP-1 gene expression and translation, as well as moderately reducing CSF-1 and
PTHrP-R expression
Thomson et al., Exp Dermatol 2003
:
We tested the
effects of
PTHrP on protein synthesis,
protein kinase A (PKA) and protein kinase C ( PKC ) activities as well as tyrosine phosphorylation in rat vibrissa dermal papilla and capsular fibroblast cells
Hastings et al., Am J Physiol Cell Physiol 2004
(Lung Neoplasms...) :
In summary,
PTHrP- ( 1-34 ) and PTHrP- ( 140-173 )
stimulate PKA in lung carcinoma cells and protect cells against UV-induced caspase-3 activation and DNA fragmentation
Shimo et al., J Bone Miner Res 2006
(Bone Neoplasms...) :
Furthermore, we found that CCN2 was
induced by
PTHrP through
PKA- , PKC-, and ERK mediated pathways therein ... CCN2 was critically involved in osteolytic metastasis and was induced by
PKA- and PKC dependent
activation of ERK1/2 signaling by
PTHrP