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IL24 — TP53

Text-mined interactions from Literome

Kokkinakis et al., Cancer Lett 2006 (Neoplasms) : Although inhibition of the cell cycle and mitosis is not necessarily dependent on the tumor 's p53 status, the expression of p21, GADD45 and apoptosis related genes ( BAX, BCL-2 ) are regulated by wt-p53 , in addition to their regulation by TGF-beta or MDA-7 in mutated p53 tumors
Sainz-Perez et al., J Immunol 2008 (Leukemia, Lymphocytic, Chronic, B-Cell) : IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression ... PSTAT3 is a transcriptional repressor of p53, and therefore IL-24 induction of p53 secondary to PSTAT3 dephosphorylation may be sensed as a stress signal and promote apoptosis in cycling cells