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PON1 — SP1

Text-mined interactions from Literome

Osaki et al., Atherosclerosis 2004 (Arteriosclerosis...) : In this study, we investigated the direct effect of Sp1 on PON1 transcription in HepG2 cells using a reporter gene assay ... In accordance with this, overexpression of Sp1 dramatically enhanced PON1 promoter activity, and the Sp1 inhibitor mithramycin inhibited Sp1 induced promoter activation in a dose dependent manner ... These data suggest that Sp1 acts as a positive regulator of PON1 transcription, and that an interaction between Sp1 and PKC is a key mechanism for the effect of Sp1 on PON1 transcription
Aviram et al., Curr Opin Lipidol 2005 (Cardiovascular Diseases) : The PON1 gene is regulated by Sp1 and protein kinase C, whereas the PON2 gene in macrophages is regulated by nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase
Ikeda et al., Metabolism 2008 : We previously demonstrated that Sp1 is a positive regulator of PON1 transcription and that an interaction between Sp1 and protein kinase C ( PKC ) is a crucial mechanism for the effect of Sp1 on PON1 transcription in cultured HepG2 cells