Chatterjee et al., J Biol Chem 2011
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Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages ... We now demonstrate that Prdx6 is required for agonist induced NOX2 activation in pulmonary microvascular endothelial cells ( PMVEC ) and that the effect requires the PLA(2) activity of Prdx6
Krishnaiah et al., FASEB J 2013
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We investigated the interaction of Prdx6 with p67(phox) and its effect on NOX2 activity
Ambruso et al., Methods Enzymol 2013
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In addition, the approach for assessing the effect of Prdx6 on Nox2 in the SDS activated, cell-free system of NADPH oxidase activity is presented ... With these approaches, the role of Prdx6 in Nox2 activity can be explored with intact cells