Gene interactions and pathways from curated databases and text-mining

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EDN1 — IL2

Text-mined interactions from Literome

Raab et al., Clin Endocrinol (Oxf) 1999 (Kidney Neoplasms...) : We investigated the effects of interleukin-2 on endothelin levels and the hypothalamo-pituitary-adrenal axis ... We determined the interleukin-6, big-endothelin , endothelin-1, ACTH, cortisol and AVP responses to intravenously and subcutaneously administered interleukin-2 in 8 cancer patients in a randomized placebo controlled trial
Shiu et al., Eur J Haematol 2002 (Anemia, Sickle Cell...) : The presence of interleukin-1 in the perfusion system, as a model for inflammatory cytokine effects, enhanced the overall amounts of released prostacyclin but did not affect the production of endothelin-1
Stankevicius et al., Medicina (Kaunas) 2003 (Arteriosclerosis...) : The synthesis of endothelin-1 is induced by hypoxia, thrombin, interleukin-1 , transforming growth factor-beta1, vasopressin, and catecholamines
Kolb et al., Z Gesamte Inn Med 1991 (Anoxia...) : The synthesis of endothelin 1 in the endothelial cells is stimulated by adrenaline, noradrenaline, angiotensin II, arginine-vasopressin, thrombine, interleukin 1 and hypoxia
Vancheeswaran et al., Arthritis Rheum 1996 (Scleroderma, Systemic...) : Furthermore, in contrast to adult disease, patients with childhood-onset disease had normal levels of parameters of vascular activation ( von Willebrand factor, angiotensin converting enzyme, E-selectin, and endothelin-1 ), T cell activation ( soluble interleukin-2 receptors ), and collagen synthesis ( carboxy-terminal type I and amino-terminal type III ), a notable lack of anticentromere antibodies, and abnormal coagulation indices