Brand et al., J Biol Chem 1998
:
We therefore examined the effect of TGF-beta1 on the expression of StAR , a mitochondrial protein implicated in intramitochondrial cholesterol transport ... It is likely that the TGF-beta1 induced decrease of StAR expression that we report here may be expanded to other steroidogenic cells in which a decrease of cholesterol accessibility to P450scc by TGF-beta1 has been hypothesized
Brand et al., Biochem Biophys Res Commun 1998
(Adrenal Cortex Neoplasms) :
Smad3 is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on StAR expression ... Here, we show that StAR expression is also inhibited by TGFbeta1 in the human adrenocortical carcinoma cell line NCI-H295R