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EGF — MARCKS
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MARCKS
→
EGF
(increases)
Olsen et al., Cell 2006*
Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database
Text-mined interactions from Literome
Iwabu et al., J Biol Chem 2004
:
Interestingly, PKCdelta is the most strongly phosphorylated isoform, and the preferential PKCdelta inhibitor rottlerin largely prevented
EGF induced phosphorylation of PKC substrates and
MARCKS
Etscheid et al., Cell Regul 1991
(Second Messenger Systems) :
Stimulation of [ 32P ] -prelabeled fibroblasts with serum, BK, vasopressin, or 12-O-tetradecanoyl phorbol acetate, but not
epidermal growth factor or calcium ionophores,
resulted in the rapid phosphorylation of
MARCKS
Micallef et al., Cancer Res 2009
(Brain Neoplasms...) :
EGFRvIII expressing or
EGF stimulated human GBM cells
increased expression, phosphorylation, and cytosolic translocation of
MARCKS in a protein kinase C-alpha dependent manner
Reynolds et al., Biochem J 1993
:
In keratinocytes, TGF-alpha and
EGF induced only a modest increase in
MARCKS protein phosphorylation