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IFNG — IL12RB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., J Immunol 1999
:
These results suggest that
IL-12R signaling
affects IFN-gamma gene transcription by at least two separate mechanisms ; IL-12R signaling without TCR signaling targets promoter regions outside of the approximately 100-bp IFN-gamma TCR-RE, and IL-12R signaling also stimulates TCR induced activity of the proximal TCR-RE
Wu et al., Eur J Immunol 2000
:
Using an antibody specific for the human IL-12Rbeta2 subunit, the
effect of
IFN-gamma , IFN-alpha, IL-12 and IL-2 on the regulation of
IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Verhagen et al., J Exp Med 2000
(Mycobacterium avium-intracellulare Infection...) :
Genetic lack of
interleukin 12 receptor beta1 ( IL-12Rbeta1 ) surface expression predisposes to severe infections by poorly pathogenic mycobacteria or Salmonella and
causes strongly decreased, but not completely abrogated,
interferon (IFN)-gamma production
Yamane et al., Eur J Immunol 2000
:
CD28 ligation induced not only IL-12Rbeta1 and beta2 mRNA expression, but also enhanced IFN-gammaR to mediate
up-regulation of
IL-12R by
IFN-gamma
Kuroda et al., J Immunol 2002
:
IFN-gamma produced by activated macrophages
induced IL-12R mRNA expression in T cells and macrophages themselves depending on their amount of IFN-gamma ; namely, macrophages from BALB/c mice induced lower expression of IL-12R
Morinobu et al., Proc Natl Acad Sci U S A 2002
:
The inability of STAT4 S721 to restore
IFN-gamma production was not
caused by decreased
IL-12R expression because the STAT4 S721 mutant also failed to restore IFN-gamma production in STAT4-deficient IL-12Rbeta2 transgenic cells
Okazawa et al., Am J Gastroenterol 2002
(Crohn Disease...) :
The functional activity of IL- 12 and IL-18 was assessed by the effect of recombinant IL-12 and recombinant IL-18 on
interferon-gamma production, the proliferative response, and the
induction of IL-2R,
IL-12R , and IL-18R of LPLs
Li et al., J Neurol Sci 2003
:
Expression of the
IL-12R subunits, IL-12Rbeta1 and IL-12Rbeta2, is upregulated in both microglia and splenic macrophages upon
stimulation with LPS or
IFN-gamma and LPS, whereas the IL-23R subunit is upregulated only in macrophages
Xu et al., Invest Ophthalmol Vis Sci 2003
(Autoimmune Diseases...) :
The parameters measured were T-cell proliferation,
IFN-gamma production,
induction of
IL-12R expression, triggering of pathogenicity, and expression of costimulatory molecules on antigen presenting cells (APCs) during in vitro exposure to antigen
Musikacharoen et al., Blood 2005
:
Promoter analyses in a mouse macrophage cell line, RAW264.7, revealed that the 2508-bp region upstream of the transcriptional start site is sufficient for the full transcriptional
activation of the
IL12RB1 gene by
IFN-gamma or IL-15 ... Consistently, IL-15, as a histone deacetylase inhibitor, synergistically enhanced
IL12RB1 gene expression and promoter
activation by
IFN-gamma through increased protein binding to ETS/PU.1 and IRE/ISRE sites ... Additionally,
IL12RB1 promoter
activation by
IFN-gamma was enhanced by the coexpression of a coactivator protein, CBP
Shin et al., J Immunol 2005
(Asthma) :
STAT4, which plays a pivotal role in Th1 immune responses, enhances
IFN-gamma transcription in
response to the interaction of IL-12 with the
IL-12R
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced
IFN-gamma , IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Kano et al., Nat Immunol 2008
:
Notably, the IRF1 dependent induction of
IL-12Rbeta1 was
essential for
IFN-gamma-IL-12 signaling but was dispensable for IL-23-IL-17 signaling