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PAK4 — RAF1

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → RAF1 (protein-protein, phosphorylation)
• WikiPathways Focal Adhesion: PAK1/PAK3/PAK2/PAK4/PAK7/PAK6 → ARAF/BRAF/RAF1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 143 proteins (association, anti tag coimmunoprecipitation)
• IRef Intact Interaction: Complex of 78 proteins (association, tandem affinity purification) Gloeckner et al., Proteomics 2007

Text-mined interactions from Literome

Sun et al., Curr Biol 2000 : Thus, Raf-1 activation by Ras is achieved through a combination of both physical interaction and indirect mechanisms involving the activation of a second Ras effector, PI 3-kinase, which directs Pak mediated regulatory phosphorylation of Raf-1
King et al., FEBS Lett 2001 : Phosphorylation site specificity of the Pak mediated regulation of Raf-1 and cooperativity with Src
Beeser et al., J Biol Chem 2005 : Inhibition of Pak reduced the Ser ( 338 ) phosphorylation of c-Raf in response to both PDGF and EGF ; however, in the case of EGF, the reduction in Ser ( 338 ) phosphorylation was not accompanied by a significant decrease in c-Raf activity