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SP1 — VHL

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VHL — SP1 (physical association, affinity chromatography technology) Yuen et al., Oncogene 2007*
• IRef Biogrid Interaction: VHL — SP1 (physical association, affinity chromatography technology) Mukhopadhyay et al., Mol Cell Biol 1997*
• IRef Biogrid Interaction: VHL — SP1 (direct interaction, pull down) Mukhopadhyay et al., Mol Cell Biol 1997*

Text-mined interactions from Literome

Cohen et al., Biochem Biophys Res Commun 1999 (Kidney Neoplasms) : Deletion of the 96-122 domain prevents VHL effects on Sp1 DNA binding and on VHL target gene expression, indicating the domain contributes importantly to VHL tumor suppressor activity
Rafty et al., J Cell Biochem 2002 : These findings thus demonstrate a pivotal role for Sp1 in pVHL inhibition of PDGF-B transcription