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NOX4 — SMAD3

Text-mined interactions from Literome

Cucoranu et al., Circ Res 2005 (Fibrosis) : Because activation of small mothers against decapentaplegic ( Smads ) 2/3 is critical for myofibroblast conversion in response to TGF-beta1, we also determined whether Nox4 affects Smad 2/3 phosphorylation ... Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation by 75+/-5 % and 68+/-3 %, respectively ( n=7, P < 0.0001 )
Ismail et al., Am J Physiol Lung Cell Mol Physiol 2009 : Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia
Boudreau et al., Free Radic Biol Med 2012 : Nox4 transcriptional regulation by TGF-beta was SMAD3 dependent based on the effect of constitutively active SMAD3 increasing Nox4 promoter activity, whereas dominant negative SMAD3 or SIS3, a SMAD3-specific inhibitor, had the opposite effect