◀ Back to IL4

IL1RN — IL4

Text-mined interactions from Literome

Mühlberg et al., J Clin Endocrinol Metab 2000 (Graves Disease) : Recent data have indicated that orbital fibroblasts ( OF ) can be stimulated to produce marked quantities of interleukin-1 receptor antagonist ( IL-1RA ), a powerful inhibitor of the proinflammatory activities of interleukin-1 in the orbital tissues in Graves ' ophthalmopathy ( GO )
Perrier et al., Clin Exp Immunol 2002 : IL-4 , which is generally described as an anti-inflammatory cytokine, increased IL-1 but not IL-1ra production
Sone et al., Nihon Kyobu Shikkan Gakkai Zasshi 1992 (Melanoma) : Marked up-regulation by IL-4 of IL-1ra production in LPS stimulated monocytes was observed at both the mRNA and protein levels
Orino et al., J Immunol 1992 : Highly purified blood monocytes, isolated by centrifugal elutriation from healthy donors, were stimulated with LPS in the presence or absence of IL-4 , and their productions of IL-1 and IL-1Ra were measured by Northern blot and immunoblot analyses ... Marked up-regulation by IL-4 of IL-1Ra production in LPS stimulated monocytes was observed at both the mRNA and protein levels ... The enhancement of IL-1Ra production by IL-4 was concluded to be due to enhanced gene transcription, because there was no difference in the half-lives of IL-1Ra mRNA in monocytes cultured with and without IL-4 ... Up-regulation of IL-1Ra production by IL-4 was also observed in monocytes stimulated with adherent IgG at both the mRNA and protein levels
Cominelli et al., Gastroenterology 1992 (Colitis) : Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis
O'Connor et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : Inhibition of PI3K with wortmannin or blockage of IRS-2/PI3K complex formation with a cell permeable IRS-2 derived tyrosine phosphopeptide inhibited IL-4 dependent IL-1RA production in db/+ macrophages ... These results indicate that in the db/db mouse model of T2D, macrophage expression of SOCS-3 is increased, and impaired IL-4 dependent IRS-2/PI3K formation induces a state of IL-4 resistance that disrupts IL-4 dependent production of IL-1RA
Pechkovsky et al., Clin Immunol 2010 (Idiopathic Pulmonary Fibrosis...) : Importantly, IL-10 enhanced IL-4 induced expression of CCL18 and IL-1RA in a synergistic fashion
Wythe et al., Ann Rheum Dis 2013 (Arthritis, Rheumatoid...) : IL-4-SyETP augmented production of IL-1 receptor antagonist (IL-1ra) by fibroblast-like synoviocytes ( FLS ) stimulated with IL-1ß in a dose dependent manner
Burger et al., J Clin Invest 1995 : The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor
Hart et al., Immunology 1995 (Arthritis) : However, only IL-4 significantly increased IL-1ra production by synovial fluid mononuclear cells ... Because IL-10 and IL-4 differentially regulate TNF-alpha and IL-1ra production by synovial fluid mononuclear cells, selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1, respectively, is established as primarily responsible for the maintenance of the chronic inflammatory condition
Mehindate et al., Infect Immun 1994 : The capacity of IL-4 to induce IL-1Ra gene expression reinforces its anti-inflammatory activity
Malyak et al., J Clin Immunol 1994 : IL-4 enhanced LPS induced IL-1ra production by PMN and inhibited LPS induced IL-1 beta production
Jenkins et al., Cytokine 1993 : However, our data confirmed that IL-4 up-regulated LPS induced IL-1ra and down-regulated LPS induced IL-1 beta
Bry et al., Am J Obstet Gynecol 1994 : Interleukin-4 stimulated the production of interleukin-1 receptor antagonist by decidual cells ( p < 0.01 ) ... Transforming growth factor-beta 1 potentiated the stimulatory effect of interleukin-4 on decidual cell interleukin-1 receptor antagonist production ( p < 0.05 )
Allen et al., J Immunol 1993 (Arthritis) : Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis
Wong et al., J Exp Med 1993 (Carcinoma, Renal Cell...) : In the presence of LPS, IL-4 not only augmented IL-1ra levels, but markedly inhibited LPS induced IL-1 mRNA expression
Vannier et al., Blood 1996 : A single amino acid mutant form of IL-4 ( hIL4.Yl24D ) induced IL-1Ra synthesis, acting as a partial agonist ... However, hIL-4.Yl24D inhibited IL-1Ra synthesis induced by either IL-4 or IL-13
Marie et al., Cytokine 1996 : IL-4 and TGF-beta were able to increase the production of IL-1ra , however only IL-4 were able to further increase IL-1ra production in the presence of LPS ... When IL-1ra production by PMN was induced by tumour necrosis factor-alpha (TNF-alpha), IL-10 and IL-4 both amplified its release and its presence as a cell associated form
Kovalovsky et al., Eur J Immunol 1998 : In the present work we examined the regulation of IL-1Ra by Th1 cytokine IFN-gamma, Th2 cytokine IL-4 , glucocorticoids and IL-1 in human monocytes
Liu et al., J Immunol 1998 : IFN-beta induces IL-1Ra and augments LPS- and IL-4 induced IL-1Ra , but suppresses LPS- and IL-1 induced IL-1, shifting the balance toward the expression of the IL-1Ra ... However, IFN-gamma also suppresses the expression of IFN-beta- and IL-4 induced IL-1Ra so that IFN-gamma may enhance or suppress IL-1 activity depending on the other cytokines present ... IL-4 has similar effects to IFN-beta ; however, other anti-inflammatory cytokines, did not regulate IL-1 or IL-1Ra in human microglia
Gabay et al., Blood 1999 (Liver Neoplasms) : To examine the role of IL-4 and IL-13 in production of IL-1Ra , human primary hepatocytes and HepG2 human hepatoma cells were cultured in the presence of IL-4 or IL-13 in combination with IL-1beta and/or IL-6