Gene interactions and pathways from curated databases and text-mining

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IL8 — NAALADL1

Text-mined interactions from Literome

Uehara et al., Mol Immunol 2007 : Anti-RP3 Abs markedly promoted the release of IL-8 induced by chemically synthesized TLR and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C , TLR4-agonistic lipid A ( LA-15-PP ), TLR7/8-agonistic single stranded RNA ( ssPolyU ), TLR9-agonistic bacterial CpG DNA, NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells, although sole incubation with anti-PR3 Abs induced only a low level of IL-8
Harwani et al., Virology journal 2007 : Poly I:C ( a TLR3-ligand ) and lipopolysaccharide ( LPS, a TLR4-ligand ) inhibited HCMV and induced secretion of IL-8 and Interferon-beta (IFNbeta) in both foreskin fibroblasts and ectocervical tissue
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 potently suppressed LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and IRF3, indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Rautava et al., J Pediatr Gastroenterol Nutr 2012 : Conditioning with TGF-ß2 significantly attenuated subsequent interleukin (IL)-1ß-, TNF-a-, and poly I:C induced IL-8 and IL-6 responses in immature human IECs
Ikeuchi et al., Int Immunopharmacol 2013 : OCT treated cells produced more IL-8 than non treated cells upon stimulation with various chemically synthesized ligands : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C , TLR4-agonistic lipid A ( E. coli-type LA-15-PP ), NOD1-agonistic FK565 and NOD2-agonistic muramyldipeptide ( MDP )
St Paul et al., Res Vet Sci 2013 : Moreover, it was found that treatment with both poly I:C and CpG ODN up-regulated transcripts for type I IFNs, while only poly I:C up-regulated IL-8 transcripts and enhanced the production of nitrite