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MDM2 — SMAD4
Text-mined interactions from Literome
Yam et al., Cancer Res 1999
:
MDM2 and MDMX
inhibit the transcriptional activity of ectopically expressed
SMAD proteins ... Here we show that
MDM2 and the structurally related protein MDMX can
inhibit the transcriptional activity of ectopically expressed SMAD1,
SMAD2 , SMAD3, and SMAD4 ... Here we show that
MDM2 and the structurally related protein MDMX can
inhibit the transcriptional activity of ectopically expressed SMAD1, SMAD2, SMAD3, and
SMAD4
Chang et al., Clin Cancer Res 2013
(Carcinoma, Pancreatic Ductal...) :
We further found that
MDM2 and Bmi-1 were overexpressed in the tumorigenic HPDE cells and that Bmi-1 overexpression was
regulated by
Smad4