Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Zacharowski et al., Arterioscler Thromb Vasc Biol 2000 (Myocardial Infarction...) : LPS also caused an upregulation of the expression of intercellular adhesion molecule-1 and P-selectin , whereas LTA downregulated these molecules and attenuated the accumulation of polymorphonuclear granulocytes caused by myocardial ischemia/reperfusion
Cerwinka et al., Shock 2001 (Hypercholesterolemia) : However, hypercholesterolemia enhanced LPS induced expression of P-selectin , E-selectin, and ICAM-1 in several vascular beds, while VCAM-1 expression was unaffected ... Thrombocytopenia, induced with anti-platelet serum, did not alter LPS induced P-selectin expression in either group, suggesting that platelets do not contribute to this response
Andonegui et al., J Immunol 2002 : The results revealed a 20- to 50-fold increase in P-selectin expression in response to LPS in all wild-type tissues examined but no response in any TLR4 ( d ) tissues ... Surprisingly, there was consistently a partial, significant increase in P-selectin expression in numerous microvasculatures including skin and pancreas, but no increase in P-selectin was detected in lung, muscle, and other organs in CD14 ( -/- ) mice in response to LPS
Andonegui et al., Blood 2005 (Inflammation...) : Here we demonstrate that although platelets do not increase P-selectin expression in response to LPS , platelets bind more avidly to fibrinogen under flow conditions in a Toll-like receptor-4 (TLR4) dependent manner
Buenestado et al., JPEN J Parenter Enteral Nutr 2006 : Immunohistochemistry showed LPS induced increase in P-selectin expression attenuated by LCT and LCT-MCT but not LCT-MUFA
Kadl et al., Arthritis Rheum 2009 (Inflammation...) : LPS , but not OxPAPC, induced the expression of adhesion molecules E-selectin, P-selectin , intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
Ma et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009 : It may involve in platelet activation as an important mediator of LPS induced CD62P and CD40L expressions on platelets
Coughlan et al., J Exp Med 1994 (Neutropenia) : We report in vivo studies in which intravenous administration of lipopolysaccharide (LPS) to anesthetized rats caused a very rapid onset ( < 5 min ) of neutropenia, in association with induction of surface expression of P-selectin on microvascular endothelial cells in kidney, liver and lung ; analogous induction of P-selectin expression by cultured endothelial cells was observed in response to LPS stimulation in vitro
Eppihimer et al., Circ Res 1996 : LPS induced upregulation of P-selectin was greatest in heart and stomach, which exhibited insignificant constitutive expression of P-selectin
Pan et al., J Biol Chem 1998 : Tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) increases synthesis of P-selectin in murine but not in human endothelial cells
Pan et al., J Biol Chem 1998 : Tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) increases expression of the P-selectin gene in murine, but not in human, endothelial cells ... The presence of these elements in the murine, but not the human, P-selectin gene may explain in part why TNF-alpha or LPS stimulates transcription of P-selectin in a species-specific manner