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IL6 — KDR

Text-mined interactions from Literome

Yao et al., Biochem Biophys Res Commun 2006 : Pharmacological inhibitor of PI3K failed to inhibit IL-6 mediated VEGF overexpression, while blocking ERK1/2 with PD98059 could abolish IL-6 induced KDR overexpression ... Further, neutralizing endogenous VEGF attenuated KDR expression and phosphorylation, suggesting that IL-6 induced KDR activation is independent of VEGF stimulation
Yao et al., J Cereb Blood Flow Metab 2007 (Arteriovenous Malformations) : Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells ... Further research revealed that IL-6 could stimulate SMC proliferation, VEGF release, and KDR activation in control HCSMCs ... Inhibiting IL-6 induced KDR could reduce MMP-9 activity at least 50 % compared with the control group ( P < 0.05 )