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IL13 — IL4R

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL4R → IL13 (directlyIncreases, IL13 Activity)
  Evidence: Figure 1. Pathways to MUC5AC expression in COPD
• KEGG Cytokine-cytokine receptor interaction: IL13 → Complex of IL13RA1-IL4R (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: IL4R — IL13 (physical association, biochemical) Obiri et al., J Biol Chem 1995
• IRef Hprd Interaction: IL13 — IL4R (in vivo) Howard et al., Am J Hum Genet 2002*
• IRef Intact Interaction: Complex of 13 proteins (direct interaction, x-ray crystallography) LaPorte et al., Cell 2008*
• MIPS Negatome - no physical interaction between proteins Interaction: IL4R — IL13 (Absence of interaction, affinity chromatography technologies) Zurawski et al., J Biol Chem 1995*
• MIPS Negatome - no physical interaction between proteins Interaction: IL4R — IL13 (Absence of interaction, text mining, MI:0405) Zurawski et al., Immunol Today 1994*
• IRef Ophid Interaction: IL4R — IL13 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Frost et al., Bone 2001 : However, the antibodies did not affect the IL-4/-13 induced inhibition of [ ( 3 ) H ] -thymidine incorporation or the stimulation of alkaline phosphatase (ALP), suggesting that IL-4Ralpha does not mediate these effects of IL-4/-13 in hOBs
Hirst et al., Am J Respir Crit Care Med 2002 : Activation of IL-4Ralpha by IL-13 or IL-4 induced signal transducer and activation of transcription-6 ( STAT6 ), p42/ p44 ERK, p38, and to a lesser extent, SAPK/JNK mitogen activated protein kinase phosphorylation
Madden et al., J Immunol 2002 : Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6
Finkelman et al., J Immunol 2005 (Bronchial Hyperreactivity) : Although IL-4 signals through two receptors, IL-4R alpha/common gamma-chain ( gamma(c) ) and IL-4R alpha/IL-13R alpha1, and only the latter is also activated by IL-13 , IL-13 contributes more than IL-4 to goblet cell hyperplasia and airway hyperresponsiveness in murine asthma
Padilla et al., J Immunol 2005 : Conversely, IL-13 given by inhalation to naive mice increased the expression of MHC II and costimulatory molecules by CD11c ( high ) cells in an IL-4Ralpha dependent manner
Andrews et al., J Immunol 2006 : These data demonstrate that IL-4Ralpha plays a key role in the binding affinity of both IL-13R and IL-4R complexes
Webb et al., J Immunol 2007 (Asthma...) : Because IL-4Ralpha is critical for IL-4 and IL-13 signaling, we also determined how variants of IL-4Ralpha influenced immune cell function
Kasaian et al., Biochem Pharmacol 2008 (Asthma...) : On B cells, monocytes, epithelial cells, and smooth muscle cells, IL-13 acts through the IL-13Ralpha1/IL-4Ralpha complex to directly induce activation responses that contribute to atopic disease
Barner et al., Curr Biol 1998 (Strongylida Infections) : Our results suggest that IL-13 regulates Th2 responses to nematode infection and requires IL-4R alpha