◀ Back to IL2

IL2 — SOAT1

Text-mined interactions from Literome

Zhou et al., Mol Cell Biol 2000 : Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling : activation of syk depends on Jak3 ; however, neither Syk nor Lck is required for IL-2 mediated STAT activation ... However, neither supported IL-2 induced STAT activation, nor did dominant negative alleles of these kinases inhibit ... However, IL-2 mediated Jak3/Stat activation is not dependent on Lck or Syk
Yu et al., J Immunol 2000 : However, one T cell line bearing a mutant gammac exhibited impaired endocytosis of IL-2, despite normal IL-2 induced Jak/STAT activation
Gollob et al., J Immunol 2000 (Immunologic Deficiency Syndromes...) : This impairment of STAT activation was specific for IL-12, as STAT activation by IL-2 , IL-15, and IFN-gamma was unaffected
Cacalano et al., Nat Cell Biol 2001 : A tyrosine mutant of SOCS-3 still blocks STAT phosphorylation, but also strongly inhibits IL-2 dependent activation of ERK and cell proliferation
Tkaczuk et al., Am J Transplant 2002 (MAP Kinase Signaling System) : Effect of anti-IL-2Ralpha antibody on IL-2 induced Jak/STAT signaling ... Under these circumstances, IL-2 mediated Jak/STAT pathway activation might be generated through residual intermediate affinity IL-2Rbetagamma receptors, and this was demonstrated by complete blockade of signaling when anti-IL-2Rbeta monoclonal antibody was added
Kryworuchko et al., Clin Exp Immunol 2003 : Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2 induced Jak/STAT signalling in human CD4 T lymphocytes
Poehlmann et al., Am J Reprod Immunol 2006 : Interleukin-2 increases CD71, STAT3 , perforin expression and cytotoxic potential of NK cells
Fujii et al., Biochem Biophys Res Commun 2007 : Here, I showed that Jak3 expression is dispensable for IL-2 induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R reconstituted fibroblast cell line
Mortarini et al., Clin Cancer Res 2009 (Melanoma...) : Serum from advanced melanoma patients inhibited IL-2 dependent STAT activation in donors ' T cells and a neutralizing monoclonal antibody to transforming growth factor beta1 counteracted such inhibition
Karitskaya et al., Pflugers Arch 2010 : The pharmacological inhibition of IL-2 induced MEK/ERK or JAK/STAT cascades suppressed the IL-2 induced proliferation and reduced the functional and protein expressions of Na, K-ATPase
Lin et al., Arthritis Rheum 2010 (Arthritis, Experimental) : Ex vivo, WYE-151650 suppressed IL-2 induced STAT phosphorylation, but not IL-6 induced STAT phosphorylation, as measured in whole blood
Frank et al., Proc Natl Acad Sci U S A 1995 : Interleukin 2 signaling involves the phosphorylation of Stat proteins
Seidel et al., Proc Natl Acad Sci U S A 1995 (Carcinoma, Hepatocellular...) : We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the STAT complexes activated by IFN-gamma, interleukin (IL) 6, granulocyte-macrophage colony stimulating factor, and IL-4
Beadling et al., EMBO J 1994 : Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes
Yu et al., J Biol Chem 1997 : Activation of Jak and STAT proteins by IL-2 is transient and the mechanism for the subsequent down-regulation of their activity is largely unknown