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IL10 — TGFB1

Text-mined interactions from Literome

Stearns et al., Clin Cancer Res 1999 (Neoplasm Metastasis...) : ELISAs further showed that TGF-beta1 expression induced matrix metalloproteinases-2 (MMP-2) expression, whereas IL-10 down-regulated MMP-2 expression while up regulating TIMP-1 in the transfected cells
Othieno et al., Infect Immun 1999 : TGF-beta1 induced monocyte IL-10 ( but not tumor necrosis factor alpha ) production ( by 70-fold, P < 0.02 ) and mRNA expression in the absence but not in the presence of PPD ... Thus, TGF-beta1 and IL-10 together potentiate the downmodulatory effect on M. tuberculosis induced T-cell production of IFN-gamma, and TGF-beta1 alone enhances IL-10 production
Ofosu-Appiah et al., J Autoimmun 1999 (Glomerulonephritis...) : While the renal inflammatory cell infiltration and expression of interleukin-4 (IL-4) and IL-10 were markedly suppressed, no local enhancement of transforming growth factor-beta ( TGF-beta ) was detected
David et al., Gene Ther 2000 : Importantly, adenovirus derived IL-10 modified the functional status of leukocytes by inducing a significant decrease in IFN-gamma production but significantly increased transforming-growth factor beta 1 ( TGF-beta 1 ) expression within the grafts compared with those treated with Addl324
Schiött et al., Immunol Lett 2000 : TGF-beta1 induced IL-10 production, slightly decreased TNF-alpha production and decreased IFN-gamma production
Suberville et al., Eur Cytokine Netw 2001 : Since differences exist between the transcriptional regulation of human and mouse IL-10, the studies reported here examined whether TGF-beta1 up-regulated IL-10 production by human monocytes/macrophages as well ... In addition, TGF-beta1 suppressed induction of IL-10 by three different stimuli other than PMA ... TGF-beta1 inhibition of IL-10 protein release was associated with proportional changes in IL-10 mRNA accumulation as assessed by quantitative kinetic ELISA PCR ... This would result from a decrease in IL-10 gene transcription as TGF-beta1 did not affect IL-10 mRNA stability, and TGF-beta1 limited the luciferase activity in cells transfected with reporter gene constructs containing 1,308 bp of the 5 ' non coding sequence of human IL-10 gene ... Thus, the present study provides the first evidence that TGF-beta1 prevents IL-10 production by human monocytic cells at a transcriptional level
von der Weid et al., Clin Diagn Lab Immunol 2001 : In contrast, IL-10 was maintained and transforming growth factor beta ( TGF-beta ) was markedly induced in a dose dependent manner
Yamauchi et al., Biochem Biophys Res Commun 2002 : Furthermore, the involvement of TGF-beta1 in the inhibition of IL-10 release by TSP-1 was indicated by the facts that ( i ) TSP-1 induced activation of TGF-beta1 produced by the U937 cells, ( ii ) exogenously added TGF-beta1 inhibited IL-10 release, and ( iii ) antibody against TGF-beta1 blocked the inhibition of IL-10 release by TSP-1
Ortegel et al., Lung Cancer 2002 (Carcinoma, Non-Small-Cell Lung...) : When added to TIL cultures stimulated with anti-CD3+IL-2, IL-4 and IL-10 enhanced and TGF-beta1 suppressed the development of TIL cytolytic activity against autologous tumor cells
Mizrachi-Nebenzahl et al., Clin Exp Immunol 2003 (Disease Progression...) : Analysis of mRNA expression of cytokines in the spleen revealed no alterations in tumour necrosis factor (TNF)-alpha, transforming growth factor ( TGF ) -beta , interleukin (IL)-12 and interferon (IFN)-gamma and induction of IL-10 and IL-4
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1 , tumor necrosis factor, or vehicle in the presence or absence of transforming growth factor-beta
Kitani et al., J Exp Med 2003 (Fibrosis) : In addition, using a self inactivating retrovirus luciferase reporter construct we showed that TGF-beta1 induces Smad4, which then binds to and activates the IL-10 promoter ... Taken together, these findings suggest that the induction of IL-10 by TGF-beta1 is not fortuitous, but instead fulfills important requirements of TGF-beta1 function after its secretion by regulatory T cells
Barbarin et al., Am J Respir Cell Mol Biol 2004 (Disease Models, Animal...) : Thus the net profibrotic activity of IL-10 in vivo appears to be mediated by its ability to stimulate the expression of the profibrotic cytokine TGF-beta1 while suppressing the expression of cyclooxygenase-2 and thus production of the antifibrotic eicosanoid PGE2
Gunnlaugsdottir et al., Int Immunol 2005 (Necrosis) : Interestingly, TGF-beta1 induced IL-10 and TNFalpha secretion
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Xiong et al., Zhonghua Wai Ke Za Zhi 2005 (Liver Cirrhosis, Experimental) : To investigate the effect of interleukin-10 (IL-10) on the expression of transforming growth factor-beta(1) ( TGFbeta(1) ) and platelet derived growth factor ( PDGF ) in hepatic stellate cells (HSC) during liver injury
Sashinami et al., Cytokine 2006 (Salmonella Infections, Animal) : Treatment of monoclonal antibodies against cytokines showed that IFN-gamma and interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection, and IFN-gamma, TNF-alpha and transforming growth factor-beta ( TGF-beta ) were involved in maintenance of growth of this bacterium on day 30 after infection
Shi et al., World J Gastroenterol 2006 (Liver Cirrhosis) : To study the effect of interleukin-10 (IL-10) on the expression of transforming growth factor beta1 ( TGF-beta1 ) in hepatic fibrosis rats and the anti-fibrotic role of exogenous IL-10
Babel et al., J Nephrol 2006 (Diabetic Nephropathies...) : Since TNF-alfa and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insufficiency - dominant features of end-stage renal disease ( ESRD ), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure
Fueki et al., Respiration 2007 : Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells
Pyrovolaki et al., Eur J Haematol 2007 (Neutropenia) : Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia ... Excessive production of TGF-beta1 within the BM microenvironment of CIN patients results in downregulation of IL-10 and reduction of myeloid progenitor cells
Zhao et al., J Huazhong Univ Sci Technolog Med Sci 2007 : Effect of TGF-beta1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats
Perez et al., J Immunol 2008 (Diabetes Mellitus, Type 1) : Preferential costimulation by CD80 results in IL-10 dependent TGF-beta1 ( + ) -adaptive regulatory T cell generation ... These observations demonstrate not only that CD80 preferentially binds to CTLA-4 but also that interaction during Ag presentation can result in IL-10 dependent TGF-beta1 ( + ) regulatory T cell induction, reinstating the potential of approaches to preferentially engage CTLA-4 through CD80 during self-Ag presentation in suppressing autoimmunity
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Yang et al., Zhonghua Nan Ke Xue 2009 (Autoimmune Diseases...) : IL-10 could relieve inflammatory infiltration of the prostate tissue and inhibit the expressions of TNF-alpha and TGF-beta1 in EAP rats, which is suggestive of its therapeutic efficacy for autoimmune prostatitis
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta, IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27, IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Díaz-Valdés et al., Cancer Res 2011 (MAP Kinase Signaling System...) : Induction of monocyte chemoattractant protein-1 and interleukin-10 by TGFbeta1 in melanoma enhances tumor infiltration and immunosuppression
Link et al., J Neuroimmunol 1995 (Inflammation...) : Transforming growth factor-beta 1 suppresses autoantigen induced expression of pro-inflammatory cytokines but not of interleukin-10 in multiple sclerosis and myasthenia gravis
Link et al., Acta Neurol Scand Suppl 1994 (HIV Infections...) : Recombinant ( r ) TGF-beta 1 dose-dependently suppressed MBP induced upregulation of the proinflammatory cytokines IFN-gamma, IL-4, IL-6, tumor necrosis factor-alpha, ( TNF-alpha ), TNF-beta and perforin, but not of the immunosuppressive and probably advantageous IL-10
Matthes et al., Eur J Immunol 1995 : On the other hand, and in contrast to the suppression of B cell proliferation and Ig secretion, the basal or the IL-6/IL-10 stimulated Ig secretion of nonproliferating cells was not inhibited by recombinant TGF-beta 1
Kitani et al., J Immunol 1994 : In contrast, SAC plus TGF-beta 1 does not induce C alpha 2 mature transcripts, even in the presence of exogenous IL-10 ; such transcripts are induced, however, by T cell stimuli such as anti-CD40 ( presented by CDw32 transfected L cells ) in the presence of TGF-beta 1/IL-10 or by PWM activated T cells
Van Vlasselaer et al., J Cell Biol 1994 : Interleukin 10 inhibits transforming growth factor-beta ( TGF-beta ) synthesis required for osteogenic commitment of mouse bone marrow cells
Reinhold et al., J Interferon Cytokine Res 1995 : Transforming growth factor beta 1 inhibits interleukin-10 mRNA expression and production in pokeweed mitogen stimulated peripheral blood mononuclear cells and T cells ... Here we have analyzed the effects of TGF-beta 1 on IL-10 and IL-1RA production in pokeweed mitogen stimulated peripheral blood mononuclear cells ( PBMC ) and purified T lymphocytes ... We show in these systems that TGF-beta 1 at a concentration of 10 ng/ml significantly suppresses both IL-10 mRNA expression and IL-10 production ... IL-2 and IL-6 were capable of abolishing the effect of TGF-beta 1 on DNA synthesis and production of IL-10 by T lymphocytes in an additive manner
Xu et al., Kidney Int 1995 : Our investigation demonstrated that : ( a ) intragraft expression of IL-10 mRNA and IL-2 mRNA are significant correlates of acute rejection ; ( b ) IL-4, IL-7, IFN-gamma and TGF-beta 1 mRNA expression do not correlate with acute rejection ; and ( c ) IL-10 does not prevent in vivo expression of IFN-gamma, IL-2, IL-7, or TGF-beta 1
Kumar et al., J Cell Physiol 1996 : Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells
Marth et al., Eur J Immunol 1997 : Regulation of transforming growth factor-beta production by interleukin-12
Giacalone et al., Exp Dermatol 1998 (Pemphigoid, Bullous) : Although a clear explanation of this phenomenon is lacking, the data presented in this report agree with a strong decrease of IL-7 production at the local level ( keratinocyte is known to produce IL-7 and the latter is known to be down-regulated by IL-10 , and in other models also by TGF-beta1 and IL-4, whose levels are elevated in BP BFs ) as opposed to an increased peripheral release of the same modulator
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra