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BAX — VDAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BAX — VDAC1 Narita et al., Proc Natl Acad Sci U S A 1998
• IRef Bind_translation Interaction: BAX — VDAC1 (unspecified method) Narita et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: VDAC1 — BAX (direct interaction, pull down) Weng et al., J Biol Chem 2005*
• IRef Biogrid Interaction: VDAC1 — BAX (direct interaction, pull down) Shi et al., Biochem Biophys Res Commun 2003*
• IRef Hprd Interaction: VDAC1 — BAX (in vitro) Shi et al., Biochem Biophys Res Commun 2003*, Narita et al., Proc Natl Acad Sci U S A 1998
• IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Mppi Interaction: BAX — VDAC1 (coimmunoprecipitation) Narita et al., Proc Natl Acad Sci U S A 1998
• IRef Ophid Interaction: BAX — VDAC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shimizu et al., Proc Natl Acad Sci U S A 2000 (Ion Channel Gating) : Furthermore, BH4 oligopeptides of Bcl-2 and Bcl-x ( L ), but not mutant peptides, were able to inhibit both VDAC activity on liposomes even in the presence of Bax and apoptotic Deltapsi loss in isolated mitochondria
Shimizu et al., J Cell Biol 2001 : Furthermore, we used these antibodies to show that Bax- and Bak induced lysis of red blood cells was also mediated by the VDAC on plasma membrane
Roucou et al., Biochem J 2002 : The presence of the voltage dependent anion channel was not required either for Bax oligomerization or for Bax induced cytochrome c release
Godlewski et al., Anticancer Drugs 2002 (Colonic Neoplasms) : A similar pattern of subcellular redistribution and colocalization of BAX with BID and BAX with VDAC-1 suggests that BAX ( in association with BID ) controls the function of VDAC-1 and its permeability for apoptogenic factors released from mitochondria of COLO 205 cells stimulated to apoptosis with NIM
Tajeddine et al., Oncogene 2008 : VDAC1 inhibition strongly reduced the CDDP induced conformational activation of Bax , yet had no discernible effect on the activation of Bak, suggesting that VDAC1 acts downstream of Bak and upstream of Bax
Ozaki et al., Biochim Biophys Acta 2009 : This cleavage of VDAC promotes the mitochondrial accumulation of Bax and the release of tAIF from mitochondria