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DVL1 — WNT3

Text-mined interactions from Literome

Strovel et al., J Biol Chem 2000 : PP2C exists in a complex with Dvl , beta-catenin, and Axin, a negative regulator of Wnt signaling
Habas et al., Cell 2001 : Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates Wnt induced Dvl-Rho complex formation
Shiomi et al., Curr Biol 2003 (Eye Abnormalities) : In the canonical pathway, Wnt receptors activate Dishevelled ( Dvl ) , which then blocks the degradation of a key signal transducer, beta-catenin, leading to the nuclear accumulation of beta-catenin and induction of Wnt target genes through TCF/LEF family transcription factors
Habas et al., Genes Dev 2003 : Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex
González-Sancho et al., Mol Cell Biol 2004 : Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that Dvl phosphorylation is not sufficient to activate canonical Wnt/beta-catenin signaling ... We conclude that Wnt induced phosphorylation of Dvl is independent of LRP5/6 receptors and that canonical Wnts can elicit both LRP dependent ( to beta-catenin ) and LRP independent ( to Dvl ) signals
Bryja et al., Proc Natl Acad Sci U S A 2007 : Inhibition of Wnt signaling by CK1 inhibitors reduced the binding of beta-arrestin to Dvl
Gan et al., J Cell Biol 2008 : Disrupting the interaction of Dvl with either c-Jun or beta-catenin suppresses canonical Wnt signaling stimulated transcription, and the reduction of Dvl diminished beta-catenin-TCF-4 association on Wnt target gene promoters in vivo
Etheridge et al., PLoS Genet 2008 (Heart Defects, Congenital...) : Interestingly, global canonical Wnt signaling appeared largely unaffected in the double Dvl mutants, suggesting that low Dvl levels are sufficient for functional canonical Wnt signals
Gao et al., Cell Signal 2010 : In addition, Dvl plays important roles in Wnt-GSK3beta-microtubule signaling, Wnt-calcium signaling, Wnt-RYK signaling, Wnt-atypical PKC signaling, etc
Gao et al., Nat Cell Biol 2010 (Colonic Neoplasms) : Here we show that autophagy negatively regulates Wnt signalling by promoting Dishevelled ( Dvl ) degradation
Perez et al., J Cell Biol 2011 (Neointima) : Interfering with the Dvl dependent Wnt-PCP activation in a murine stented aortic graft injury model promotes extensive neointima formation, as shown by optical coherence tomography and histopathology
Wei et al., Mol Cell Biol 2012 (Wnt Signaling Pathway) : ITCH ubiquitinates the phosphorylated form of Dvl and promotes its degradation via the proteasome pathway, thereby inhibiting canonical Wnt signaling
Barry et al., Nature 2013 (Colorectal Neoplasms...) : DVL signals in the nucleus of intestinal stem cells, and its forced expression leads to enhanced Wnt signalling in crypts
Ding et al., J Biol Chem 2013 (Wnt Signaling Pathway) : Consistent with the role of Dvl in both Wnt/ß-catenin and Wnt/planar cell polarity signaling, NEDD4L regulates the cellular ß-catenin level and Rac1, RhoA, and JNK activities
Goto et al., PloS one 2013 : In Xenopus embryos, depletion of IQGAP1 reduced Wnt induced nuclear accumulation of DVL , and expression of Wnt target genes during early embryogenesis
Brigelius-Flohé et al., Methods Enzymol 2013 : NOX1 derived H2O2 oxidizes Nrx leading to the liberation of Dvl and the activation of Wnt signaling