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CDH13 — TNF
Text-mined interactions from Literome
Kikumori et al., Biochem J 2001
:
Although the expression of the
p105 gene, another known target for NF-kappaB, was
increased by
TNF-alpha in the absence of TSH, the presence of TSH further increased the mRNA level
Salmerón et al., J Biol Chem 2001
:
Tumor necrosis factor alpha (TNFalpha) and interleukin-1alpha (IL-1alpha)
stimulate p105 degradation, releasing associated Rel subunits to translocate into the nucleus
Nwariaku et al., Shock 2002
:
The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in
TNF induced changes in
cadherin expression
Lang et al., Mol Cell Biol 2003
:
IKK mediated p105 phosphorylation generates a binding site for betaTrCP, the receptor subunit of an SCF-type ubiquitin E3 ligase, and depletion of betaTrCP by RNA interference blocks
TNF-alpha induced
p105 ubiquitination and proteolysis
Demarchi et al., J Biol Chem 2003
:
Moreover,
p105 degradation in
response to
TNF-alpha is prevented in GSK-3 beta-/- fibroblasts and by a Ser to Ala point mutation on p105 at positions 903 or 907
Nwariaku et al., Blood 2004
:
We found that
tumor necrosis factor (TNF) caused tyrosine phosphorylation of
VE-cadherin , separation of lateral cell-cell junctions, and intercellular gap formation in human umbilical vein endothelial cell ( HUVEC ) monolayers
Angelini et al., Am J Physiol Lung Cell Mol Physiol 2006
:
PP2 also blocked
TNF-alpha induced tyrosine phosphorylation of
VE-cadherin , gamma-catenin, and p120(ctn)
Vandooren et al., Arthritis Rheum 2008
(Rheumatic Diseases) :
In vitro,
cadherin 11 expression by FLS was consistently
up-regulated by
tumor necrosis factor alpha (TNFalpha) at the protein, but not the messenger RNA, level
Wall et al., Science signaling 2009
(Inflammation...) :
Suppression of LPS induced
TNF-alpha production in macrophages by cAMP is
mediated by
PKA-AKAP95-p105 ... We showed a specific role for A kinase anchoring protein 95 in suppressing the expression of the gene encoding
tumor necrosis factor-alpha , which
involved phosphorylation of
p105 ( also known as Nfkb1 ) by PKA at a site adjacent to the region targeted by inhibitor of nuclear factor kappaB kinases
Parfiniewicz et al., Acta Pol Pharm 2012
:
However,
TNF-alpha did not
cause such a significant increase in
sE-cadherin level
Tan et al., Biochim Biophys Acta 1994
:
In the present study, we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene, and investigated the
effects of PAF and
TNF on
p50/p105 gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB