◀ Back to NOS2

IGF1 — NOS2

Text-mined interactions from Literome

Guan et al., Neuroscience 2000 (Brain Ischemia) : Insulin-like growth factor-1 markedly prevented the loss of calbindin-28kd ( n = 7, P < 0.05 ), choline acetyltransferase ( n = 7, P < 0.05 ), neuropeptide Y ( n = 7, P < 0.05 ), neuronal nitric oxide synthase ( n = 8, P < 0.05 ) and glutamate acid decarboxylase ( n = 9, P < 0.05 ) immunopositive neurons, but failed to protect parvalbumin ( n = 6 ) immunopositive neurons
Castrillo et al., Diabetes 2000 : Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation dependent apoptosis : involvement of phosphatidylinositol 3-kinase
Isenovic et al., Metabolism 2003 : Interactive effects of insulin-like growth factor-1 and beta-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells
Priego et al., J Endocrinol 2006 : In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6- ( 1-iminoethyl ) lysine ( l-NIL ) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures ... We conclude that in hepatocytes, LPS induced decrease in IGF-I is mainly due to induction of iNOS , whereas in the presence of Kupffer cells LPS inhibits IGF-I through NO release and through other inhibitory pathways
Thum et al., Circ Res 2007 : IGF-1 increased telomerase activity, endothelial nitric oxide synthase expression, phosphorylation and activity in EPC in a phosphoinositide-3-kinase/Akt dependent manner
Zakula et al., Med Hypotheses 2007 (Diabetes Mellitus, Experimental...) : Understanding how iNOS and sodium pump activity are regulated by IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation
Hijikawa et al., Shock 2008 (Liver Failure) : We hypothesized that IGF-1 inhibited the induction of these cytokines and iNOS , resulting in beneficial effect in the liver ... Insulin-like growth factor 1 may inhibit the induction of proinflammatory cytokines and iNOS through an nuclear factor-kappa B-independent pathway and have a novel therapeutic potential in the prevention of liver injury
Hirai et al., Life Sci 2011 (Atherosclerosis...) : In group HIGF, IGF led to atheromas with increased plasma insulin growth factor binding protein 3 ( IBP3 ), inducible nitric oxide synthase(iNOS) expression and nitrotyrosine staining, macrophage staining, SM1 staining and SM embryo staining compared to HC
Stone et al., J Gerontol A Biol Sci Med Sci 2012 : Moreover, IGF-1 also activated endothelial nitric oxide synthase in human umbilical vein endothelial cells
Guan et al., Am J Physiol 1998 : We demonstrate that both insulin and IGF-I increase IL-1 beta induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production